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Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity.
Karsdal MA, Madsen SH, Christiansen C, Henriksen K, Fosang AJ, Sondergaard BC
Arthritis Res Ther 2008, 10:R63
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Synovial fluid level of aggrecan ARGS fragments is a more sensitive marker of joint disease than glycosaminoglycan or aggrecan levels: a cross-sectional study
Larsson S, Lohmander LS, Struglics A
Arthritis Research & Therapy 2009, 11:R92 (22 June 2009)
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