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Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine.
Prichard MN, Kern ER, Quenelle DC, Keith KA, Moyer RW, Turner PC
Virol J 2008, 5:39
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Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in mice
De Silva FS, Moss B
Virology Journal 2008, 5:145 (2 December 2008)
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