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Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers.
Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG
Mol Neurodegener
2007,
2
:18
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Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity.
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In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms.
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