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A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity.
Olsson LM, Lindqvist AK, Källberg H, Padyukov L, Burkhardt H, Alfredsson L, Klareskog L, Holmdahl R
Arthritis Res Ther 2007, 9:R98
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Activation of the immune response is a key feature of aging in mice.
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