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Site-directed in vitro immunization leads to a complete human monoclonal IgG4 lambda that binds specifically to the CDR2 region of CTLA-4 (CD152) without interfering the engagement of natural ligands.
Chin LT, Chu C, Chen HM, Hsu SC, Weng BC, Chu CH
BMC Biotechnol 2007, 7:51
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