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Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution.
Bloom JD, Romero PA, Lu Z, Arnold FH
Biol Direct
2007,
2
:17
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PubMed Central articles that cite the above article:
1.
Principal component analysis of CYP2C9 and CYP3A4 probe substrate/inhibitor panels.
Nath A, Atkins W
Drug Metab Dispos
2008 Nov,
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Directed enzyme evolution: climbing fitness peaks one amino acid at a time.
Tracewell CA, Arnold FH
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