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Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly.
Holla L, Cameron J, Berge KE, Ranheim T, Leren TP
BMC Cell Biol 2007, 8:9
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1.
Self-association of human PCSK9 correlates with its LDLR-degrading activity.
Fan D, Yancey PG, Qiu S, Ding L, Weeber EJ, Linton MF, Fazio S
Biochemistry 2008 Feb 12, 47:1631-9
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