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SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells.
Goujon C, Rivière L, Jarrosson-Wuilleme L, Bernaud J, Rigal D, Darlix JL, Cimarelli A
Retrovirology 2007, 4:2
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Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.
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Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection.
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Characterization of the early steps of infection of primary blood monocytes by human immunodeficiency virus type 1.
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Vpx is critical for reverse transcription of the human immunodeficiency virus type 2 genome in macrophages.
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Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells.
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Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.
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The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection.
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Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBj.
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