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Multiple pathways contribute to the pathogenesis of Huntington disease.
Li S, Li XJ
Mol Neurodegener 2006, 1:19
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1.
Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice.
Wang J, Wang CE, Orr A, Tydlacka S, Li SH, Li XJ
J Cell Biol 2008 Mar 24, 180:1177-89
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N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.
Orr AL, Li S, Wang CE, Li H, Wang J, Rong J, Xu X, Mastroberardino PG, Greenamyre JT, Li XJ
J Neurosci 2008 Mar 12, 28:2783-92
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Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons.
Tydlacka S, Wang CE, Wang X, Li S, Li XJ
J Neurosci 2008 Dec 3, 28:13285-95
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