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The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles.
Wilkins A, Szafranski K, Fraser DJ, Bakthavatsalam D, Müller R, Fisher PR, Glöckner G, Eichinger L, Noegel AA, Insall RH
Genome Biol 2005, 6:R68
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Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs.
Kae H, Kortholt A, Rehmann H, Insall RH, Van Haastert PJ, Spiegelman GB, Weeks G
EMBO Rep 2007 May, 8:477-82
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Phosphoinositide 3-kinase activity controls the chemoattractant-mediated activation and adaptation of adenylyl cyclase.
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Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions.
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J Cell Biol 2008 Jun 2, 181:747-60
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