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Overcoming cisplatin resistance by mTOR inhibitor in lung cancer.
Wu C, Wangpaichitr M, Feun L, Kuo MT, Robles C, Lampidis T, Savaraj N
Mol Cancer 2005, 4:25
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Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment.
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Drug Resist Updat 2008 Jun, 11:63-76
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Intrinsically lower AKT, mammalian target of rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-D-glucose under hypoxia in lung cancer cell lines.
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Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins.
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