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Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation.
Mirshamsi S, Laidlaw HA, Ning K, Anderson E, Burgess LA, Gray A, Sutherland C, Ashford ML
BMC Neurosci
2004 Dec 6,
5
:54
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1.
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.
Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Brüning JC
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Leptin and its role in hippocampal synaptic plasticity.
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Rapid inhibition of neural excitability in the nucleus tractus solitarii by leptin: implications for ingestive behaviour.
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Cytoplasmic accumulation of long-chain coenzyme A esters activates KATP and inhibits Kir2.1 channels.
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Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.
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