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The Janus kinases (Jaks).
Yamaoka K, Saharinen P, Pesu M, Holt VE, Silvennoinen O, O'Shea JJ
Genome Biol 2004, 5:253
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Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo.
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Inhibition of Jak1-dependent signal transduction in airway epithelial cells infected with adenovirus.
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RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia.
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The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes.
Wernig G, Gonneville JR, Crowley BJ, Rodrigues MS, Reddy MM, Hudon HE, Walz C, Reiter A, Podar K, Royer Y, Constantinescu SN, Tomasson MH, Griffin JD, Gilliland DG, Sattler M
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Molecular characterization of human breast tumor vascular cells.
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Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor.
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Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state.
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Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2.
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Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia.
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Protein tyrosine phosphatases in the JAK/STAT pathway.
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Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550).
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J Med Chem 2008 Dec 25, 51:8012-8
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