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Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation.
Ghose R, Zimmerman TL, Thevananther S, Karpen SJ
Nucl Recept 2004 Aug 16, 2:4
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Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells.
Kim MS, Sweeney TR, Shigenaga JK, Chui LG, Moser A, Grunfeld C, Feingold KR
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Rosiglitazone attenuates suppression of RXRalpha-dependent gene expression in inflamed liver.
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