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Hypothesis: Induced angiogenesis after surgery in premenopausal node-positive breast cancer patients is a major underlying reason why adjuvant chemotherapy works particularly well for those patients.
Retsky M, Bonadonna G, Demicheli R, Folkman J, Hrushesky W, Valagussa P
Breast Cancer Res 2004, 6:R372-4
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Addition of granulocyte-colony stimulating factor (G-CSF) may further increase chemosensitive state in premenopausal node-positive breast cancer patients with induced angiogenesis after surgery.
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