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Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.
Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA
J Biol 2002 Nov 6, 1:10
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PubMed Central articles that cite the above article:

1.	Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Williams JA, Guicherit OM, Zaharian BI, Xu Y, Chai L, Wichterle H, Kon C, Gatchalian C, Porter JA, Rubin LL, Wang FY Proc Natl Acad Sci U S A 2003 Apr 15, 100:4616-21 [PubMed Central] [PubMed] [Related articles]
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3.	Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus. Merchant M, Evangelista M, Luoh SM, Frantz GD, Chalasani S, Carano RA, van Hoy M, Ramirez J, Ogasawara AK, McFarland LM, Filvaroff EH, French DM, de Sauvage FJ Mol Cell Biol 2005 Aug, 25:7054-68 [PubMed Central] [PubMed] [Related articles]
4.	Distinct roles of PTCH2 splice variants in Hedgehog signalling. Rahnama F, Toftgård R, Zaphiropoulos PG Biochem J 2004 Mar 1, 378:325-34 [PubMed Central] [PubMed] [Related articles]
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6.	The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling. Davey MG, Paton IR, Yin Y, Schmidt M, Bangs FK, Morrice DR, Smith TG, Buxton P, Stamataki D, Tanaka M, Münsterberg AE, Briscoe J, Tickle C, Burt DW Genes Dev 2006 May 15, 20:1365-77 [PubMed Central] [PubMed] [Related articles]
7.	Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion. Bijlsma MF, Spek CA, Zivkovic D, van de Water S, Rezaee F, Peppelenbosch MP PLoS Biol 2006 Jul, 4:e232 [PubMed Central] [PubMed] [Related articles]
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11.	Activation of heterotrimeric G proteins by Smoothened. Riobo NA, Saucy B, Dilizio C, Manning DR Proc Natl Acad Sci U S A 2006 Aug 15, 103:12607-12 [PubMed Central] [PubMed] [Related articles]
12.	Odontogenic keratocysts arise from quiescent epithelial rests and are associated with deregulated hedgehog signaling in mice and humans. Grachtchouk M, Liu J, Wang A, Wei L, Bichakjian CK, Garlick J, Paulino AF, Giordano T, Dlugosz AA Am J Pathol 2006 Sep, 169:806-14 [PubMed Central] [PubMed] [Related articles]
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20.	Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. Wall DS, Mears AJ, McNeill B, Mazerolle C, Thurig S, Wang Y, Kageyama R, Wallace VA J Cell Biol 2009 Jan 12, 184:101-12 [PubMed Central] [PubMed] [Related articles]
21.	Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Rohatgi R, Milenkovic L, Corcoran RB, Scott MP Proc Natl Acad Sci U S A 2009 Mar 3, 106:3196-201 [PubMed Central] [PubMed] [Related articles]
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24.	Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina. Sigulinsky CL, Green ES, Clark AM, Levine EM Dev Biol 2008 May 15, 317:560-75 [PubMed Central] [PubMed] [Related articles]
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