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The human anti-IL-1 beta monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis.
Alten R, Gram H, Joosten LA, van den Berg WB, Sieper J, Wassenberg S, Burmester G, van Riel P, Diaz-Lorente M, Bruin GJ, Woodworth TG, Rordorf C, Batard Y, Wright AM, Jung T
Arthritis Res Ther 2008, 10:R67
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NOD-like receptors and inflammation
Mathews RJ, Sprakes MB, McDermott MF
Arthritis Research & Therapy 2008, 10:228 (25 November 2008)
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