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The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes.
Palmer G, Burger D, Mezin F, Magne D, Gabay C, Dayer JM, Guerne PA
Arthritis Res Ther 2004, 6:R181-9
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Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts
Müller-Ladner U, Ospelt C, Gay S, Distler O, Pap T
Arthritis Research & Therapy 2007, 9:223 (20 December 2007)
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The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function
Kirsch BM, Zeyda M, Stuhlmeier K, Grisar J, Smolen JS, Watschinger B, Stulnig TM, Hörl WH, Zlabinger GJ, Säemann MD
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