Dan Stein and James Giordano examine the intersections between global mental health and neuroethics, highlighting that collaborations should be fostered to facilitate the development of new technologies and progress of research on a global scale.
The ADAPT-IT project explores how adaptive designs can improve clinical trials. Using the SHINE trial as an example, two designs were evaluated, revised and improved using trial simulation to facilitate the understanding of the statistical properties of both.
Recruitment to clinical trials is often challenging. A multi-center RCT recruiting stroke rehabilitation patients identified that the most successful strategies included using inclusive recruitment, ‘watchful waiting’, and structured engagement with the whole stroke multi-disciplinary team.
The first review in the "Breakthroughs in clinical epigenetics" series provides an upate on synthetic epigenetics and the potential clinical applications of epigenome editing.
Hepatitis B serologic survey in Fiji during 2008-2009 demonstrated a significant reduction of HBV infection rates in children and adults since 1998, indicating the HB immunization program is very successful.
Kathryn Maitland reviews the complications and therapeutic challenges associated with malaria in African children, discussing new clinical trial data and future research priorities to improve pediatric malaria outcome in this high-burden setting.
Patricio Lopez-Jaramillo et al. discuss the link between maternal undernutrition, birth weight and cardiometabolic disease, emphasizing the importance of conducting research in Latin America to develop strategies for disease prevention in this setting.
Early mobilization is not common across intensive care units (ICUs) in Australia and New Zealand despite physiotherapists being available; more than 50% of patients are discharged with ICU-acquired weakness as a result.
Can a new analysis of the evolutionary history of the aloes identify why Aloe vera, and not one of the 500 other Aloe species, has been so extensively used medicinally for over 2000 years?
Acromyrmex ants use domesticated bacteria to protect their cultivated fungal gardens from parasites; new experiments show that individual ant and bacteria species have co-evolved such that ants are negatively affected when inoculated with a different bacteria species.
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