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  • Image attributed to: pixabay

    Global mental health & ethics

    Dan Stein and James Giordano examine the intersections between global mental health and neuroethics, highlighting that collaborations should be fostered to facilitate the development of new technologies and progress of research on a global scale.

    BMC Medicine 2015, 13:44
  • The Stroke Hyperglycemia Insulin Network Effort (SHINE) trial: an adaptive trial design case study

    The ADAPT-IT project explores how adaptive designs can improve clinical trials. Using the SHINE trial as an example, two designs were evaluated, revised and improved using trial simulation to facilitate the understanding of the statistical properties of both.

    Trials 2015, 16:72
  • Recruiting to inpatient-based rehabilitation trials

    Recruitment to clinical trials is often challenging. A multi-center RCT recruiting stroke rehabilitation patients identified that the most successful strategies included using inclusive recruitment, ‘watchful waiting’, and structured engagement with the whole stroke multi-disciplinary team.

    Trials 2015, 16:75
  • Intelligent control of epigenetic states

    The first review in the "Breakthroughs in clinical epigenetics" series provides an upate on synthetic epigenetics and the potential clinical applications of epigenome editing.

    Clinical Epigenetics 2015, 7:18
  • Image attributed to: wikimedia commons-flickr.com/photo/34073237@N04/3526766899

    Successful HB immunization program in Fiji

    Hepatitis B serologic survey in Fiji during 2008-2009 demonstrated a significant reduction of HBV infection rates in children and adults since 1998, indicating the HB immunization program is very successful.

    Virology Journal 2015, 12:36
  • Image attributed to: istock

    Managing pediatric malaria

    Kathryn Maitland reviews the complications and therapeutic challenges associated with malaria in African children, discussing new clinical trial data and future research priorities to improve pediatric malaria outcome in this high-burden setting.

    BMC Medicine 2015, 13:42
  • Image attributed to: Wikipedia; CC Heraldry

    Preventing cardiometabolic disease

    Patricio Lopez-Jaramillo et al. discuss the link between maternal undernutrition, birth weight and cardiometabolic disease, emphasizing the importance of conducting research in Latin America to develop strategies for disease prevention in this setting.

    BMC Medicine 2015, 13:41
  • Early mobilization in mechanically ventilated patients

    Early mobilization is not common across intensive care units (ICUs) in Australia and New Zealand despite physiotherapists being available; more than 50% of patients are discharged with ICU-acquired weakness as a result.

    Critical Care 2015, 19:81
  • Image attributed to: Raul654, CC3.0

    A history of Aloe vera

    Can a new analysis of the evolutionary history of the aloes identify why Aloe vera, and not one of the 500 other Aloe species, has been so extensively used medicinally for over 2000 years?

    BMC Evolutionary Biology 2015, 15:29
  • Image attributed to: Deadstar0, CC3.0

    For ants and bacteria, compatibility matters

    Acromyrmex ants use domesticated bacteria to protect their cultivated fungal gardens from parasites; new experiments show that individual ant and bacteria species have co-evolved such that ants are negatively affected when inoculated with a different bacteria species.

    BMC Evolutionary Biology 2015, 15:27
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