Alcohol consumption in the UK rises during adolescence and declines in mid-life, but frequent drinking is more common in older age, particularly among men, providing information about drinking patterns that could inform intervention strategies.
Endocrine therapy is the standard of care for patients with hormone receptor positive (HR+) breast cancer; Angelo Di Leo and colleagues review current treatment issues in postmenopausal patients, discussing strategies to overcome hormonal therapy resistance.
Fei Chen and colleagues discuss the role of the tumor microenvironment (TME) in cancer progression, highlighting ways in which the TME can be targeted to improve therapeutic efficacy and reduce resistance in a personalized approach to cancer therapy.
Dan Stein and James Giordano examine the intersections between global mental health and neuroethics, highlighting that collaborations should be fostered to facilitate the development of new technologies and progress of research on a global scale.
The first review in the "Breakthroughs in clinical epigenetics" series provides an upate on synthetic epigenetics and the potential clinical applications of epigenome editing.
Recruitment to clinical trials is often challenging. A multi-center RCT recruiting stroke rehabilitation patients identified that the most successful strategies included using inclusive recruitment, ‘watchful waiting’, and structured engagement with the whole stroke multi-disciplinary team.
The ADAPT-IT project explores how adaptive designs can improve clinical trials. Using the SHINE trial as an example, two designs were evaluated, revised and improved using trial simulation to facilitate the understanding of the statistical properties of both.
Yehuda Shoenfeld and colleagues review the challenges with diagnosis and management of neuropsychiatric lupus, and explore the possible link between disease symptoms and specific mechanisms which may help to inform development of future therapies.
Hepatitis B serologic survey in Fiji during 2008-2009 demonstrated a significant reduction of HBV infection rates in children and adults since 1998, indicating the HB immunization program is very successful.
Kathryn Maitland reviews the complications and therapeutic challenges associated with malaria in African children, discussing new clinical trial data and future research priorities to improve pediatric malaria outcome in this high-burden setting.
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