In a randomized trial, an equation based on procalcitonin and pyuria reduces prescription of antibiotics for urinary tract infections (UTIs) without affecting clinical outcome, suggesting that algorithms could reduce inappropriate antibiotic use.
Wollstein and Lao discuss the most widely used methods in population genetics for evaluating individual genetic ancestry.
As part of the "Human Evolutionary Genomics" thematic series, Michael Hofreiter and colleagues review how recent technological improvements have rapidly transformed ancient human DNA research to become a central component of modern anthropological research.
Alfgeir Kristjansson and Inga Dora Sigfusdottir discuss the use of electronic cigarettes (ECs) in adolescents, concluding that ECs are likely to increase the risk of other harmful behaviours such as alcohol use, so their use should be restricted in minors.
Wei-Qi Wei and Joshua Denny review how the combination of data extracted from EHRs with high-throughput genotyping information can accelerate genomic discovery.
In an analysis of epidemiological and clinical data, recent outbreaks of Chikungunya virus in Brazil are caused by imported strains, suggesting surveillance and vector mitigation measures are required to avoid uncontrolled transmission in America.
A multiplex assay for simultaneous detection of H7N9 and influenza A viruses was developed, enabling the laboratory surveillance and rapid diagnosis of these viruses in the future.
Treatment of NV-01, a monoclonal canine-specific antibody against nerve growth factor, decreased pain and improved mobility in dogs with degenerative joint disease-associated pain, with the magnitude of the effect appearing identical to that expected with an NSAID.
Viroj Tangcharoensathien and colleagues discuss the forthcoming Sustainable Development Goals (SDGs), highlighting the importance of incorporating universal health coverage within these goals in order to accelerate health equity.
A new genome editing method facilitates generation of functional cassette knockin in mice
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