Using massive parallel sequencing of DNA from dogs and wolves, the authors have found 155 new genetic variants of canine Toll-like receptors, primary sensors of pathogens in the body.
In an analysis of patient records in the US, hospitalization and mortality rates for acute myocardial infarction (AMI) have declined overall in the past 18 years, but race and sex disparities remain, suggesting that further efforts to improve equity are required.
Neuromodulators disrupt the network synchrony characteristic of cortical neurons in culture - but not for ever. Even with a dose-calibrated application, synchrony reemerges after about 12 hours and a withdrawal period is needed to restore efficacy.
Mark Jobling addresses concerns over misinterpreting population genetics research, and it's potential to exacerbate racism.
New evidence that methylation beyond the CpG island could play a role in gene expression.
Multimorbidity occurs in over 10% of survey respondents in southern China, and secondary care is used preferentially over primary care by those with multimorbidities, suggesting that a stronger primary care system needs to be developed for these patients.
Analysis of giraffe mitochondrial DNA supports the existence of an ancient rift valley that once separated populations in southern Africa and created the genetically distinct subspecies seen today; results with implications for both giraffe conservation and taxonomy.
In this forum article, experts discuss non-communicable diseases (NCDs) that, despite causing significant health issues, do not receive the attention they deserve, highlighting the need for higher global health priority to reduce the burden of disease.
Epigenetic modifications such as histone and DNA methylation are essential for silencing pluripotency genes. A critical step is identified for the self-renewal and differentiation of embryonic stem cells.
Explaining why ethics and informed consent processes for genomic studies need to be more transparent in the case of vulnerable African populations.
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