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  • Seizures in an immunocompromised youth

    Immunocompromised patients are at higher risk of contracting tuberculosis with atypical presentations. A 17 year-old man presented with focal fits progressing to epilepsia partialis continua. Mycobacterium tuberculosis was detected in the cerebrospinal fluid and successfully treated.

    Journal of Medical Case Reports 2015, 9:184
  • Predicting chromatin compartments

    A method for predicting a sequence’s localization in the A or B compartment of the nucleus based on chromatin data

    Genome Biology 2015, 16:180
  • Image attributed to: flickr; doviende

    ADHD linked to mathematical ability

    In a systematic review, the inattentive component of attention deficit/hyperactivity disorder (ADHD) has a stronger negative association with mathematical ability than the hyperactive component, highlighting that ADHD domains could have differential etiology.

    BMC Medicine 2015, 13:204
  • Image attributed to: From Fig 1 Pelletier and colleagues

    DNA-PK inhibition boosts Cas9-mediated HDR

    Transient pharmacological inhibition of DNA-PKcs can stimulate homology-directed repair following Cas9-mediated induction of a double strand break, and is expected to reduce the downstream workload.

    Genome Medicine 2015, 7:93
  • Image attributed to: Figure 6

    3D plant cell culture

    A new technique borrows from biomedical engineering to study plant cells in culture conditions that mimic tissue scaffolds, allowing for a more physiologically relevant way to explore cell-environment interactions.

    BMC Plant Biology 2015, 15:211
  • In-nucleus ligation Hi-C

    A comparison of in-nucleus and in-solution ligation protocols for Hi-C finds that the former gives much more consistent results

    Genome Biology 2015, 16:175
  • Barley domestication

    Robin Allaby discusses the origins of barley, and what this means for our understanding of the evolution of domesticated crops

    Genome Biology 2015, 16:176
  • RF associated with higher RA disease scores

    The presence of rheumatoid factor (RF) has a clear association with high levels of disease activity in rheumatoid arthritis (RA) patients whereas autoantibodies against citrullinated proteins (APCA), the characteristic marker, does not.

    Arthritis Research & Therapy 2015, 17:229
  • Astrocytes in the sleeping and awake brain

    Does the state of the brain - whether asleep, awake, or sleep-deprived - affect astrocytes (or vice versa)? Profiling of ribosome-associated mRNAs identifies changes in gene expression, while 3-d imaging at nanometer resolution reveals a retraction of astrocytic processes from neural synapses during sleep.

    BMC Biology 2015, 13:66
  • Image attributed to: CC Bernard Dupont

    Resilient Chimpanzee populations

    A large-scale census of chimpanzees in the fragmented forests of Uganda reveals populations that are three times larger than previously estimated.

    BMC Ecology 2015, 15:21
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    Reproducibility: what are we going to do about it?

    As an increasing number of studies reveal that much of science is not able to be reproduced or replicated, BioMed Central launched the pilot of a new Minimum Standards of Reporting Checklist.

    The checklist addresses three areas of reporting: experimental design and statistics, resources, and availability of data and materials.

    As well as posting a blog to summarize the main features, a launch editorial was published, where BioMed Central staff and the Editors of GigaScience and Genome Biology stressed the need for ensuring the reproducibility of scientific work.

     

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    Tropical Diseases, Travel Medicine and Vaccines has launched

    This is the first open access journal in the field of travel medicine and the first journal to focus on intersecting topics in tropical diseases, travel medicine and vaccines.  Considering the increased mobility of world populations and increasing globalization of world economies, the journal meets the growing need for the dissemination of research with strong implications for world health and medicine.


    Read more about it in the editorial 'The local importance of global infectious diseases'.

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    Chinese Neurosurgical Journal has now fully launched

    The journal covers all areas of neurosurgery, including new trends in neurology and neuroscience, with a focus on clinical practice and techniques. We publish it on behalf of the Chinese Neurosurgical Association, which fully sponsors the article processing charges for authors.

    The Editor-in-Chief Jizong Zhao is a leading expert in neurosurgery in China and also an academician of Chinese Academy of Sciences.

    Click here to find out why you should publish in this journal.

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    Women’s Midlife Health has fully launched

    "We seek to stimulate increased scientific and clinical focus on the midlife and its relevance to health and healthy aging," says Editor-in-Chief Dr. Siobán D. Harlow of the University of Michigan. Find out more about the aims of the journal in her launch editorial

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