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  • PLINK: The Next Generation

    As an extremely popular toolset for genome-wide association studies and population genetics analyses, PLINK has had a dramatic makeover: faster, more compatible and able to handle the latest feature rich and massive datasets

    GigaScience 2015, 4:7
  • Image attributed to: Raul654, CC3.0

    A history of Aloe vera

    Can a new analysis of the evolutionary history of the aloes identify why Aloe vera, and not one of the 500 other Aloe species, has been so extensively used medicinally for over 2000 years?

    BMC Evolutionary Biology 2015, 15:29
  • Early mobilization in mechanically ventilated patients

    Early mobilization is not common across intensive care units (ICUs) in Australia and New Zealand despite physiotherapists being available; more than 50% of patients are discharged with ICU-acquired weakness as a result.

    Critical Care 2015, 19:81
  • Computer-aided discovery of new breast cancer therapeutics

    A combination of virtual screening and biochemical assays identified new small-molecule estrogen receptor inhibitors with the potential for use in novel endocrine-based therapies.

    Breast Cancer Research 2015, 17:27
  • Image attributed to: Xocolatl, Public Domain

    Where does the house mouse come from?

    Although a key model species in biology, the evolutionary origins of the house mouse are poorly understood; a new phylogeographic analysis highlights Iran as a focal point of initial diversification of these animals, which have since conquered the world.

    BMC Evolutionary Biology 2015, 15:26
  • Altering cancer transcriptomes using epigenomic inhibitors

    Peggy Farnham and colleagues provide new insights into the mechanism of epigenetic inhibition of the WNT pathway in cancer therapy.

    Epigenetics & Chromatin 2015, 8:9
  • Image attributed to: istock

    High burden of mortality in smokers

    In Australia, which has high historical but low current prevalence of smoking, up to two thirds of deaths in current smokers are due to tobacco but cessation reduces mortality, providing independent evidence about the contemporary risks of smoking.

    BMC Medicine 2015, 13:38
  • Is the relationship among outcome variables shown in randomized trials?

    Randomized controlled trials often measure multiple outcomes, including primary, secondary and harms. However, the relation between outcomes is rarely stated for both individual outcomes and for the components of composite outcomes.

    Trials 2015, 16:57
  • Image attributed to: istock

    Infection and cancer therapy

    Barbara Burtness and Mehmet Altan comment on research showing an increased risk of severe infection in cancer patients on EGFR-directed antibody therapy, highlighting that dose modification strategies could be developed to reduce infection risk. 

    BMC Medicine 2015, 13:37
  • miRNAs in CLL onset and progression

    Carlo Croce and colleagues review the roles of a few key miRNAs in chronic lymphocytic leukemia (CLL) and the potential for identifying new biomarkers and treatment approaches.

    Journal of Hematology & Oncology 2015, 8:12
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