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  • Image attributed to: Taken from

    Beyond ENCODE?

    In their open peer reviewed correspondence piece, Tagu and colleagues discuss the opportunities afforded by neoENCODE initiatives to understand how genetic systems react in the natural context of living ecosystems. Do comment!

    BMC Genomics 2014, 15:490
  • Image attributed to: CC-BY 2.0 Greg Friese

    Epinephrine injectors inadequate for intramuscular delivery

    Current EpiPen® needle length may not be adequate for intramuscular delivery of epinephrine in women with food allergies, potentially impacting upon effective treatment of anaphylaxis.

    Allergy, Asthma & Clinical Immunology 2014, 10:39
  • Image attributed to: Geo Swan on Wikipedia

    Longer stay linked to TB

    Despite measures to prevent infection spread the number of days spent in hospital in Botswana is strongly associated with development of tuberculosis (TB) within 12 months of discharge, and with TB-related mortality.

    BMC Infectious Diseases 2014, 14:409
  • Protective effect of galantamine on brain atrophy rate

    Acetylcholinesterase inhibitor galantamine lowered the rate of whole brain atrophy, but not hippocampal atrophy, in mild cognitive impairment patients that carried the ε4 allele of apolipoprotein E only.

    Alzheimer's Research & Therapy 2014, 6:47
  • Image attributed to: Paul Wicks

    Video Q&A: Patient-led research

    Paul Wicks, Vice President of PatientsLikeMe, answers our questions about the challenges and benefits of participant-led research, discussing how this will influence future research, as well as its potential impact on personalized medicine.

    BMC Medicine 2014, 12:118
  • Image attributed to: Bastique on Wikipedia

    Decline in HIV-1 resistance mutations

    HIV-1 mutations associated with the individual drug components of HAART in treatment failing patients have declined, regardless of specific class combinations and epidemiological characteristics of treated population, likely due to the improvements in HIV treatment such as prescription guidelines.

    BMC Infectious Diseases 2014, 14:398
  • Image attributed to: istock

    Ratio of blood cells predicts TB risk

    An increased ratio of blood monocytes to lymphocytes (ML) in South African infants aged 3 to 4 months is associated with tuberculosis (TB) risk in the first two years of life, suggesting the ML ratio may help identify at-risk infants.

    BMC Medicine 2014, 12:120
  • Image attributed to: Toshimasa Ishibashi on Flickr

    Challenges of 'cocooning'

    The implementation of ‘cocooning’, via immunization of close contacts, to protect newborns from pertussis is challenging and usually remains incomplete, with parents often lacking knowledge of both the threats and transmission of this disease.

    BMC Infectious Diseases 2014, 14:397
  • Inflammation and acid-base components

    Acid-base abnormalities, such as increased strong ion gap or decreased albumin, are associated with immunological activation; this association cannot be explained by illness severity alone.

    Critical Care 2014, 18:R154
  • Image attributed to: Flickr CC: Neeta Lind

    Worse polytrauma outcomes for diabetics

    Patients with diabetes have worse outcomes after suffering polytrauma compared with patients without past medical co-morbidities, indicating that early identification and targeted monitoring of diabetic patients may result in improved outcomes.

    BMC Medicine 2014, 12:111
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