Beerenwinkel and colleagues describe a method identifying hits from large-scale RNAi screens and removing confounding effects due to miRNA-mediated off-target interactions
This Editorial sets the scene for the series in which we encounter the difficulties of treating antibiotic-resistant gonorrhoea and Mycoplasma genitalium; the continuing spread of chlamydia, syphilis and trichomoniasis, as well as management of non-gonococcal urethritis and bacterial vaginosis.
Bereaved relatives of those who died from cancer report that dying at home is associated with less grief and more peace compared with dying in hospital, but requires more family care, suggesting that discussion of preferences is needed.
Non-adherence to disease-modifying antirheumatic drugs in the first six months of treatment is a strong predictor of higher disease activity and thus contributes to failure in obtaining remission.
During warmer years Swedish sand lizards lay their eggs earlier, a trait strongly linked to offspring survival, suggesting that for this population at the northern extremes of reptile ranges a warming climate could be beneficial.
The great problem with the evolutionary origin of eukaryotes is the absence of intermediates. Eugene Koonin sets the recent startling discovery of the Lokiarchaea in the context of the complex issues arising in the attempt to fill the gap between bacteria and modern eukaryotes.
Evidence from meta-analyses suggests that some commonly-used drugs show only minimal clinically important benefits, indicating that physician training may be required to prevent overtreatment and emphasize evidence-based medicine.
Harin Karunajeewa comments on research identifying determinants of early parasite clearance following artemisinin-based malaria treatment, highlighting that the findings should enable early detection of artemisinin resistance in African populations.
Expression of XIST from exogenous sites induces perinuclear localization at each site, plus a variable extent of silencing
This unique case report describes a 32-year-old woman presenting with nausea and vomiting. Clinical signs were compatible with ketoacidosis, which was linked to a low carbohydrate, high fat diet, and potentially aggravated by breastfeeding.
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