As an extremely popular toolset for genome-wide association studies and population genetics analyses, PLINK has had a dramatic makeover: faster, more compatible and able to handle the latest feature rich and massive datasets
Patricio Lopez-Jaramillo et al discuss the link between maternal undernutrition, birth weight and cardiometabolic disease, emphasizing the importance of conducting research in Latin America to develop strategies for disease prevention in this setting.
Can a new analysis of the evolutionary history of the aloes identify why Aloe vera, and not one of the 500 other Aloe species, has been so extensively used medicinally for over 2000 years?
Early mobilization is not common across intensive care units (ICUs) in Australia and New Zealand despite physiotherapists being available; more than 50% of patients are discharged with ICU-acquired weakness as a result.
Although a key model species in biology, the evolutionary origins of the house mouse are poorly understood; a new phylogeographic analysis highlights Iran as a focal point of initial diversification of these animals, which have since conquered the world.
A combination of virtual screening and biochemical assays identified new small-molecule estrogen receptor inhibitors with the potential for use in novel endocrine-based therapies.
In Australia, which has high historical but low current prevalence of smoking, up to two thirds of deaths in current smokers are due to tobacco but cessation reduces mortality, providing independent evidence about the contemporary risks of smoking.
Peggy Farnham and colleagues provide new insights into the mechanism of epigenetic inhibition of the WNT pathway in cancer therapy.
Randomized controlled trials often measure multiple outcomes, including primary, secondary and harms. However, the relation between outcomes is rarely stated for both individual outcomes and for the components of composite outcomes.
Barbara Burtness and Mehmet Altan comment on research showing an increased risk of severe infection in cancer patients on EGFR-directed antibody therapy, highlighting that dose modification strategies could be developed to reduce infection risk.
- Editor's picks in my subject areas
- Information for authors
- OA and developing world
- Information for librarians
- BioMed Central Members
- Information for advertisers
- Open Repository
- Publishing services
- Additional services
- Reasons to publish
- Press centre
- Social networks
- BioMed Central events
- Reprints and permissions
- Biome magazine