Carol Sibley discusses recent findings on the genetic changes associated with artemisinin resistance in P. falciparum parasites, highlighting the importance of understanding the evolution of resistance to maintain antimalarial effectiveness.
Sweden, a country at a late stage of epidemiological transition, has exceeded the target of 25% reduction in premature mortality due to non-communicable diseases (NCDs), suggesting other countries at earlier stages of development may achieve this goal.
Sanchez-Mejias and Tay review recent discoveries that implicate competing endogenous RNAs (ceRNAs), or natural miRNA sponges, in human cancer. The authors explain how identifying ceRNA
regulatory networks can aid the development of new approaches to cancer diagnostics and oligonucleotide-based therapeutics.
The design and allocation of participants in a study could affect behavior and bias findings. However, the study design and allocation of participants in a self-reported alcohol consumption study did not affect drinking behavior.
As the methodological aspects to a systematic review develop, the key principles behind them may need to be reevaluated to address more complex questions and interventions; for example, future research should focus on publication bias in qualitative research and the incorporation of a systems perspective.
Epigenetic effects of endocrine disrupting chemicals in germ cells are corrected by germline reprogramming events in the next generation
In this podcast, Richard Legro, an obstetrician and gynecologist, answers our questions on the diagnosis and treatment of polycystic ovary syndrome (PCOS) and highlights the controversies associated with therapies for infertility in PCOS.
Evidence from randomized trials suggests that taking selective estrogen receptor modulators could reduce breast cancer risk; Victor Vogel comments on the latest results, recommending that the risks and benefits should be considered for each individual.
Following revision of the International Classification of Diseases, the European Commission Expert Group on Rare Diseases recommends health care coding systems to use ORPHA codes in addition to ICD10 codes for rare diseases.
Emma Whitelaw and colleagues explore the genome-wide consequences of the absence of a recently-identified epigenetic modifier, reporting effects on methylation at thousands of loci in embryonic mice, with a bias towards activity at CpG island shores and enhancers.
- Editor's picks in my subject areas
- Information for authors
- OA and developing world
- Information for librarians
- BioMed Central Members
- Information for advertisers
- Open Repository
- Publishing services
- Additional services
- Reasons to publish
- Press centre
- Social networks
- BioMed Central events
- Reprints and permissions
- Biome magazine