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    Antipsychotics: costs and care

    Previous research suggested a need for increased prescribing of generic risperidone in Western Europe; Michael Berk and colleagues argue for a balance between cheapest drug use and optimal tailored care to ensure beneficial patient outcomes.

    BMC Medicine 2014, 12:126
  • Reparative activity of pericardial ADSCs

    Although phenotypically identical, pericardial adipose tissue-derived stromal cells (ADSCs) in comparison to subcutaneous ADSCs were shown to exhibit potent differentiation towards cardiomyocytes and induced significant structural repair in the injured heart.

    Stem Cell Research & Therapy 2014, 5:92
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    Children at risk of epinephrine injection into bone

    Epinephrine may be injected into the bone of anaphylactic children weighing under 15kg, implying that further research is needed to determine the appropriate needle length for pediatric patients.

    Allergy, Asthma & Clinical Immunology 2014, 10:40
  • A novel vaccine for tau immunotherapy

    Active vaccine AADvac1 validates the novel tau target revealed by monoclonal antibody DC8E8 by reducing Alzheimer's disease-type tau hyperphosphorylation by 95% in transgenic rats, and has now entered phase I clinical trials.

    Alzheimer's Research & Therapy 2014, 6:44
  • A novel target for tau immunotherapy

    Monoclonal antibody DC8E8 disables a novel target on tau protein essential for its pathological function both in vitro and in vivo, and is a suitable candidate molecule for Alzheimer's disease immunotherapy.

    Alzheimer's Research & Therapy 2014, 6:45
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    The evolution of a butterfly supergene

    Female mocker swallowtail butterflies show a remarkable variety of wing patterns, each mimicking a different poisonous butterfly species; a new study provides insights into the evolution of the supergene locus that makes these polymorphisms possible.

    BMC Evolutionary Biology 2014, 14:140
  • Image attributed to: Figure from DawnRank by Ma

    Finding personalized cancer drivers

    It is a challenge to assess whether rare and patient-specific mutations are cancer drivers. The algorithm DawnRank prioritizes altered genes on a single patient level.

    Genome Medicine 2014, 6:56
  • Image attributed to: Abramsky et al. (2014)

    Community intervention reduces IPV

    In a randomized trial, a community-based intervention aiming to prevent intimate partner violence (IPV) and HIV-risk behaviors in Uganda successfully reduced acceptance and incidence of IPV, and is now being delivered in other communities.

    BMC Medicine 2014, 12:122
  • Physical activity and cellular aging in breast cancer survivors

    A self-reported lack of physical activity was associated with shortened telomere length in early stage breast cancer survivors, suggesting a mechanism by which exercise can reduce cellular aging.

    Breast Cancer Research 2014, 16:413
  • Next-generation sequencing in microbial forensics

    High throughput sequencing (HTS) for microbial forensics has the potential to solve crimes and enhance public safety, however, interpretation of the results relies on understanding the performance and limitations of HTS methods. Bruce Budowle and colleagues present new criteria to be considered for HTS validation for microbial forensics.

    Investigative Genetics 2014, 5:9
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    Military Medical Research has now launched

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