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  • Benchmarking mutation predictors

    Comparison of mutation predictors shows that no single algorithm is the best and that combination of predictors improves negative predictive value

    Genome Biology 2014, 15:484
  • RNA polymerase crosstalk

    RNA polymerase III complexes, when bound to DNA, regulate RNA polymerase II transcription of neighboring genomic regions.

    BMC Biology 2014, 12:89
  • MSEA: mutation hotspots

    MSEA detects cancer genes by targeting unique characteristics of mutation hotspots with improved precision and reduced false positive discovery

    Genome Biology 2014, 15:489
  • Image attributed to: Image credit: Baum and Baum, BMC Biology 2014

    Inside-out origins - how eukaryotes began

    How far could a proto-eukaryote have got before it swallowed its proto-mitochondria? Not far enough to provide the energy for phagocytosis to swallow them, say David and Buzz Baum, who have developed an alternative to the accepted theory for the origin of eukaryotes

    BMC Biology 2014, 12:76
  • Image attributed to: Flickr (CC, Lars Ploughman)

    Triple P program has short-term advantages

    In a randomized controlled trial, the parenting support program Stepping Stones Triple P effectively reduces psychosocial problems in children with disabilities over a 3 month period, but not after 6 months, suggesting short-term benefits of the program.

    BMC Medicine 2014, 12:191
  • Image attributed to: From Fig 6 of Lyon and colleagues

    INDEL calling WGS versus WES

    Characterization of calling errors for INDEL detection using Scalpel shows that calling improves with higher coverage,  is better with assembly-based callers is discordant between WGS and WES.

    Genome Medicine 2014, 6:89
  • Image attributed to: From Fig 1 of Hrdlickova and colleagues

    ‘Guilt by association’ in AID

    Genome-wide association studies mapped 90% of loci linked to autoimmune and immune-related diseases to non-coding regions.  A ‘guilt by association’ approach suggests a role for lncRNAs in autoimmunity.

    Genome Medicine 2014, 6:88
  • Image attributed to: istock photo

    Depression and cardiovascular risk

    Peter de Jonge and Annelieke Roest comment on research published in BMC Cardiovascular Disorders showing a J-shaped relationship between cardiometabolic risk factors and depression, highlighting the need to consider non-linear associations in medicine

    BMC Medicine 2014, 12:199
  • Image attributed to: breast tumor via Wikimedia commons

    Immune metagene roles in therapy response

    Gene expression signatures of infiltrating immune cells provide prognostic and therapy-predictive information for breast cancer and are affected by tumor proliferative capacity and intrinsic subtype.

    Genome Medicine 2014, 6:80
  • Dosage compensation in C. elegans

    A new study confirms the long-standing hypothesis that dosage compensation complex activity results in X chromosome compaction when equalizing X-linked gene expression between sexes.

    Epigenetics & Chromatin 2014, 7:31
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BioMed Central news

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    Journal of Compassionate Health Care (JCHC) has now fully launched

    This is the first open access journal that publishes leading research and perspectives in the growing field of compassionate health care. Read the Q+A with the Editors-in-Chief, Sue Shea and Christos Lionis, to find out more about the field and what they hope to achieve with the journal. 
    Click on the following links to dip into the first two research articles published and a case study by Robin Youngson, an international leader in compassionate healthcare.

     

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    Journal of Clinical Movement Disorders (JCMD) has now launched and published its first articles

    Edited by Dr Steven Frucht, JCMD focuses on scientific investigations into the diagnosis, evaluation and management of patients with involuntary movement disorders. The journal reviews, illustrates and emphasizes clinical phenomenology as an indispensable tool for the diagnosis and application of translational medicine to movement disorders. It also covers topics including Parkinson's disease, tremor, dystonia, myoclonus, Huntington's disease, tics, and pediatric movement disorders.

    For more information, please read the launch Editorial and an Editor Q&A with Dr Frucht published today in Biome.

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    Safety in Health is accepting submissions

    The journal encompasses global trends in healthcare affecting quality and safety. This includes patient safety, training and simulation, health economics, quality and process management, as well as critical incidents including the legal or regulatory aspects.

    For those wishing to submit a manuscript, click on the link for the instructions for authors and information about the journal's policies

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    Eye and Vision has fully launched

    We are delighted to announce that Eye and Vision has now fully launched with BioMed Central and published its first articles.

    Eye and Vision, supported by Wenzhou Medical University, is an interdisciplinary journal which covers both ophthalmology and optometry. It aims to keep the ophthalmologists and visual science specialists up-to-date with the latest development in theoretical, experimental and clinical investigations in eye and vision. In doing so, it will promote the exchange of innovative ideas and advanced information worldwide.

    For more information please take a look at the launch editorial by Editor-in-Chief, Prof. Jia Qu. 

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