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  • Tumor heterogeneity

    Charles Swanton and colleagues review the ins and outs of intratumor heterogeneity and how does it affect personalized medicine

    Genome Biology 2014, 15:453
  • N-of-1 studies

    Obi Griffith, Andrew Su and colleagues discuss the challenges of combining the genomic knowledge and N-of-1 studies to improve personalized medicine

    Genome Biology 2014, 15:438
  • Gastric cancer N-of-1

    David Adams and colleagues discuss the elegant approach for the cancer evolution studies, combining sequencing with the clever choice of cancer models

    Genome Biology 2014, 15:444
  • Gastric cancer evolution

    Tumor evolution in a diffuse gastric cancer patient and cancer modeling reveals the metastatic contribution of Tgfbr2 loss-of-function

    Genome Biology 2014, 15:428
  • Kidney cancer evolution

    An analysis of sporadic renal cell carcinoma case reveals new insights about evolutionary principles affecting tumor development

    Genome Biology 2014, 15:433
  • SubcloneSeeker

    A new statistical framework for the reconstruction of tumor clone structure

    Genome Biology 2014, 15:443
  • Image attributed to: Figure from Irizarry and colleagues

    Hypomethylated blocks are a feature of cancer

    A comprehensive genome-scale study of multiple solid tumors showed that hypomethylated blocks are a universal feature of common solid tumors and occur early in malignancy.

    Genome Medicine 2014, 6:61
  • Hepatocellular carcinoma genomics

    Whole genome and transcriptome sequencing of matched tumor-normal tissue for hepatocellular carcinoma cases reveals low frequency mutations associated with the disease

    Genome Biology 2014, 15:436
  • Image attributed to: istock

    Update on CVD risk factors

    Specific factors are associated with risk of cardiovascular disease; Robert Eckel and Marc-Andre Cornier review the data and recommendations on the use of these biomarkers to help identify patients who need intensive cholesterol-lowering therapy.

    BMC Medicine 2014, 12:115
  • Image attributed to: Krupovic et al. BMC Biology 2014

    The origin of CRISPR-Cas immunity

    Hickman and Dyda discuss a new superfamily of mobile elements, designated casposons, that are likely to be bona fide DNA transposons, and are possibly still active.

    Mobile DNA 2014, 5:23
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