Beerenwinkel and colleagues describe a method identifying hits from large-scale RNAi screens and removing confounding effects due to miRNA-mediated off-target interactions
This Editorial sets the scene for the series in which we encounter the difficulties of treating antibiotic-resistant gonorrhoea and Mycoplasma genitalium; the continuing spread of chlamydia, syphilis and trichomoniasis, as well as management of non-gonococcal urethritis and bacterial vaginosis.
In an economic evaluation comparing extensions of the pre-2013 influenza vaccination program to various age groups, extending vaccine administration in children in the UK may be cost-effective and reduce disease burden in the general population.
High total cholesterol is a risk factor for rheumatoid arthritis (RA) in women but not in men, suggesting that sex-specific exposures modify the impact of lipids on the risk of RA.
In an editorial to launch our article collection on cardiovascular diseases, Guest Editor Richard Hobbs emphasizes research should focus on better diagnosis and interventions, and discusses how this collection aims to address some of the gaps in knowledge in the field.
Bereaved relatives of those who died from cancer report that dying at home is associated with less grief and more peace compared with dying in hospital, but requires more family care, suggesting that discussion of preferences is needed.
Non-adherence to disease-modifying antirheumatic drugs in the first six months of treatment is a strong predictor of higher disease activity and thus contributes to failure in obtaining remission.
During warmer years Swedish sand lizards lay their eggs earlier, a trait strongly linked to offspring survival, suggesting that for this population at the northern extremes of reptile ranges a warming climate could be beneficial.
In a cohort study, voluntary repeat HIV testers are likely to engage in more risky sexual behaviors compared with single-testers, suggesting that analysis of testing patterns could reveal which groups are at highest risk of infection.
The great problem with the evolutionary origin of eukaryotes is the absence of intermediates. Eugene Koonin sets the recent startling discovery of the Lokiarchaea in the context of the complex issues arising in the attempt to fill the gap between bacteria and modern eukaryotes.
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