No lizard lives at higher altitudes than P.erythrurus, which makes it home high on the Tibetan plateau; new research provides insights into the genetic changes this species has undergone to adapt to life in such a challenging environment.
DNMT1-dependent and –independent methylation patterns play distinct roles in mouse embryonic stem cell genome stability and transcriptional regulation
In an analysis of pregnant women undergoing non-invasive prenatal screening (NIPS), the positive predictive value for fetal chromosomal disorders is 77.4%, highlighting that abnormal results cannot be considered diagnostic and genetic testing should be offered.
Patients with sepsis-associated acute respiratory distress syndrome (ARDS) on continuous statin therapy have lower 28-day mortality risk than those not taking statins, suggesting a survival benefit of statin therapy in this patient group.
The authors introduce two non-invasive methods for acquiring viable cells with primary cilia from ciliopathy patients, deriving cells from urine and milk teeth.
In a systematic review of self-management interventions for asthma, effective strategies utilize a combination of patient engagement and training of healthcare professionals, indicating that self-management support should be implemented in clinical practice.
The Illumina MiSeq and MinION nanopore sequencer yield actionable clinical information on a Salmonella outbreak in less than half a day
Roles for ZFP57-mediated regulation of genomic imprinting and a novel mechanism for genetically determined mono-allelic gene expression.
Parental smoking exacerbates poverty for a large proportion of children in the UK, suggesting tobacco control interventions which effectively enable low income smokers to quit can play an important role in reducing the financial burden of child poverty.
Risk factors for non-communicable diseases (NCDs) are prevalent in Tanzanaia and Uganda, but the incidence of preventable NCDs is low, highlighting the need for prevention campaigns and early detection efforts to reduce NCD burden in Africa.
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