Peter Croft et al. argue that decision making in clinical practice should be based on patient prognosis as well as disease diagnosis, highlighting that this prognostic model may improve future patient outcome by incorporating more information.
In a mathematical model, the timing of infection by Plasmodium falciparum malaria mostly depends on random factors, suggesting that parasite growth rate could be more useful than time-to-infection measures in estimating protective immunity.
Lyketsos and colleagues review the current literature on the phenomenology and diagnosis, neurobiology, and treatment approaches for several key behavioral phenotypes in Alzheimer’s disease.
As part of the cerebral multi-morbidity series, Baker and Götz review the contribution that transgenic animal models have made to a better mechanistic understanding of the causes and consequences of co- or multi-morbidity.
Exposure to cigarette smoke leads to sex-specific epigenetic changes and disruption to key metabolic pathways in human fetal liver tissue (from 11-21 weeks of gestation), highlighting the impact of maternal smoking in early pregnancy.
miRNA sequencing in diffuse large B-cell lymphoma reveals many novel miRNAs, as well as some that are associated with survival
A relationship between disease subtype in chronic lymphocytic leukemia and variation in gene expression suggests that variability has an effect on tumor adaptability and aggressiveness.
A novel method combining flow-sorting to separate tumor populations by ploidy with high-throughput sequencing shows promise to trace genome evolution in human cancer.
Disease-specific Bayesian models provide a robust, accurate and transparent framework to integrate multiple sources of evidence for the interpretation of novel variants from gene sequencing.
A lipid-based nutritional supplement (LNS) with added micronutrients does not decrease mortality in malnourished HIV-infected adults compared with LNS alone, but improves the CD4 count, suggesting this intervention may provide clinical benefits.
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