As an extremely popular toolset for genome-wide association studies and population genetics analyses, PLINK has had a dramatic makeover: faster, more compatible and able to handle the latest feature rich and massive datasets
Can a new analysis of the evolutionary history of the aloes identify why Aloe vera, and not one of the 500 other Aloe species, has been so extensively used medicinally for over 2000 years?
Early mobilization is not common across intensive care units (ICUs) in Australia and New Zealand despite physiotherapists being available; more than 50% of patients are discharged with ICU-acquired weakness as a result.
A combination of virtual screening and biochemical assays identified new small-molecule estrogen receptor inhibitors with the potential for use in novel endocrine-based therapies.
Peggy Farnham and colleagues provide new insights into the mechanism of epigenetic inhibition of the WNT pathway in cancer therapy.
In Australia, which has high historical but low current prevalence of smoking, up to two thirds of deaths in current smokers are due to tobacco but cessation reduces mortality, providing independent evidence about the contemporary risks of smoking.
Randomized controlled trials often measure multiple outcomes, including primary, secondary and harms. However, the relation between outcomes is rarely stated for both individual outcomes and for the components of composite outcomes.
Carlo Croce and colleagues review the roles of a few key miRNAs in chronic lymphocytic leukemia (CLL) and the potential for identifying new biomarkers and treatment approaches.
Barbara Burtness and Mehmet Altan comment on research showing an increased risk of severe infection in cancer patients on EGFR-directed antibody therapy, highlighting that dose modification strategies could be developed to reduce infection risk.
How is organ size regulated? Khammash and colleagues address this central mystery of biology with a mathematical model, and in an accompanying Commentary Charles Stevens explains why this is not ‘just a theory’.
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