Steven LeVine and colleagues review the possible risks and benefits of using aspirin to reduce cardiovascular risk for multiple sclerosis (MS) patients, concluding that population-based studies are needed to establish guidance for aspirin use in MS.
In an analysis of two randomized controlled trials evaluating the addition of local anesthetic wound infiltration (LAI) to standard analgesia after hip and knee replacement, LAI is cheaper than standard care, so could be a cost-effective treatment option.
The last ice age substantially shaped distributions of the spotted snow skink, a reptile found only in Tasmania, but in differing ways between north-western and south-eastern populations, patterns which could be replicated in other species.
Treating cancer in patients with learning disabilities can be challenging; Robert Huddart and colleagues discuss the management of testicular cancer in those with Down syndrome, concluding that a high cure rate can be achieved with appropriate therapy.
A bloom of cytochrome P450 encoding genes in the parsley family, resulting from a proliferation of gene duplications, gives insights into the evolution of chemicals crucial to plants in protecting themselves against insects.
Advantages over clinical exome sequencing can be achieved by using an NGS-based multiplexing assay involving comprehensive gene panels.
Abigail Caudle and Henry Kuerer review the management of lymph node metastases in breast cancer, highlighting that axillary lymph node dissection is no longer necessary in all patients, and discussing ways in which surgery could be reduced in the future.
In a randomized controlled trial, a nurse-designed screening intervention for domestic violence (DV) in postpartum women leads to better safety planning over 36 months, highlighting the importance of healthcare worker involvement in DV prevention.
Greg Gibson, Joseph Powelland Urko Marigorta review the current use of expression quantitative trait loci for understanding disease and highlight areas that it will be useful translational medicine.
Research Excellence Framework (REF) is a new system for assessing quality of UK research; here Saba Hinrichs and Jonathan Grant describe how information from case studies can be used to explore how research outcomes contribute to various levels of impact and health gains.
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