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  • Standing variation and adaptation

    Selective sweep mapping in chickens reveals that standing genetic variation makes a considerable contribution to the long-term response to selection

    Genome Biology 2015, 16:219
  • Image attributed to: NIAID CC2.0

    Treating sexually transmitted infections

    This Editorial sets the scene for the series in which we encounter the difficulties of treating antibiotic-resistant gonorrhoea and Mycoplasma genitalium; the continuing spread of chlamydia, syphilis and trichomoniasis, as well as management of non-gonococcal urethritis and bacterial vaginosis.

    BMC Infectious Diseases 2015, 15:337
  • Lokiarchaea and the missing link

    The great problem with the evolutionary origin of eukaryotes is the absence of intermediates. Eugene Koonin sets the recent startling discovery of the Lokiarchaea in the context of the complex issues arising in the attempt to fill the gap between bacteria and modern eukaryotes.

    BMC Biology 2015, 13:84
  • Image attributed to: iStock Photo

    Are common medications effective?

    Evidence from meta-analyses suggests that some commonly-used drugs show only minimal clinically important benefits, indicating that physician training may be required to prevent overtreatment and emphasize evidence-based medicine.

    BMC Medicine 2015, 13:253
  • Image attributed to: Wikipedia; Computerhotline

    Monitoring antimalarial resistance

    Harin Karunajeewa comments on research identifying determinants of early parasite clearance following artemisinin-based malaria treatment, highlighting that the findings should enable early detection of artemisinin resistance in African populations.

    BMC Medicine 2015, 13:251
  • XIST and localization

    Expression of XIST from exogenous sites induces perinuclear localization at each site, plus a variable extent of silencing

    Genome Biology 2015, 16:208
  • Ketoacidosis associated with low-carbohydrate diet in a non-diabetic lactating woman

    This unique case report describes a 32-year-old woman presenting with nausea and vomiting. Clinical signs were compatible with ketoacidosis, which was linked to a low carbohydrate, high fat diet, and potentially aggravated by breastfeeding.

    Journal of Medical Case Reports 2015, 9:224
  • The third enzyme

    Nowhere is the evolution of protein diversity faster than in immunity. Insect innate immunity has benefited from a proliferation of phenol oxidases, most recently in fruitflies, Bruno Lemaitre and colleague suggest, with the appearance of PO3 response to selective pressure from parasitic wasps.

    BMC Biology 2015, 13:81
  • tRNAs and inherited conditions

    Work on primordial dwarfism provides new insights into links between tRNA modification and inherited conditions in humans

    Genome Biology 2015, 16:216
  • Image attributed to: Figure 2

    Increased volume of ‘questionable’ articles

    The number of articles published in open access journals with questionable marketing and peer review practices, has increased by nearly eight times since 2010 and authors are predominantly based in Asia and Africa.

    BMC Medicine 2015, 13:230
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