Selective sweep mapping in chickens reveals that standing genetic variation makes a considerable contribution to the long-term response to selection
This Editorial sets the scene for the series in which we encounter the difficulties of treating antibiotic-resistant gonorrhoea and Mycoplasma genitalium; the continuing spread of chlamydia, syphilis and trichomoniasis, as well as management of non-gonococcal urethritis and bacterial vaginosis.
The great problem with the evolutionary origin of eukaryotes is the absence of intermediates. Eugene Koonin sets the recent startling discovery of the Lokiarchaea in the context of the complex issues arising in the attempt to fill the gap between bacteria and modern eukaryotes.
Evidence from meta-analyses suggests that some commonly-used drugs show only minimal clinically important benefits, indicating that physician training may be required to prevent overtreatment and emphasize evidence-based medicine.
Harin Karunajeewa comments on research identifying determinants of early parasite clearance following artemisinin-based malaria treatment, highlighting that the findings should enable early detection of artemisinin resistance in African populations.
Expression of XIST from exogenous sites induces perinuclear localization at each site, plus a variable extent of silencing
This unique case report describes a 32-year-old woman presenting with nausea and vomiting. Clinical signs were compatible with ketoacidosis, which was linked to a low carbohydrate, high fat diet, and potentially aggravated by breastfeeding.
Nowhere is the evolution of protein diversity faster than in immunity. Insect innate immunity has benefited from a proliferation of phenol oxidases, most recently in fruitflies, Bruno Lemaitre and colleague suggest, with the appearance of PO3 response to selective pressure from parasitic wasps.
Work on primordial dwarfism provides new insights into links between tRNA modification and inherited conditions in humans
The number of articles published in open access journals with questionable marketing and peer review practices, has increased by nearly eight times since 2010 and authors are predominantly based in Asia and Africa.
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