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  • Parallel sequencing reveals new genetic variants of Toll-like receptors in dogs and wolves

    Using massive parallel sequencing of DNA from dogs and wolves, the authors have found 155 new genetic variants of canine Toll-like receptors, primary sensors of pathogens in the body.

    Canine Genetics and Epidemiology 2014, 1:11
  • Image attributed to: istock photo

    A framework for authorship

    Ana Marušić and colleagues present a five-step framework to establish authorship of industry-sponsored clinical trial publications early in the manuscript development process, with the aim of standardizing decisions and facilitating transparency.

    BMC Medicine 2014, 12:197
  • Image attributed to: istock photo

    Attributing authorship in trials

    Transparent documentation of clinical trial authorship is important; David Moher comments on Marušić and colleagues’ five-step authorship framework, highlighting the responsibilities of authors and ways in which the framework could be implemented.

    BMC Medicine 2014, 12:214
  • Image attributed to: istock photo

    Race and sex disparities occur in AMI

    In an analysis of patient records in the US, hospitalization and mortality rates for acute myocardial infarction (AMI) have declined overall in the past 18 years, but race and sex disparities remain, suggesting that further efforts to improve equity are required.

    BMC Medicine 2014, 12:190
  • Image attributed to: Image credit: Wikipedia

    An inevitable reemergence of network synchrony

    Neuromodulators disrupt the network synchrony characteristic of cortical neurons in culture - but not for ever. Even with a dose-calibrated application, synchrony reemerges after about 12 hours and a withdrawal period is needed to restore efficacy.

    BMC Biology 2014, 12:83
  • Trouble at the races

    Mark Jobling addresses concerns over misinterpreting population genetics research, and it's potential to exacerbate racism.

    Investigative Genetics 2014, 5:14
  • Image attributed to: Flickr, e-MagineArt.com

    Multimorbidity common in southern China

    Multimorbidity occurs in over 10% of survey respondents in southern China, and secondary care is used preferentially over primary care by those with multimorbidities, suggesting that a stronger primary care system needs to be developed for these patients.

    BMC Medicine 2014, 12:188
  • Image attributed to: Roland H. CC2.0

    A rift among giraffes

    Analysis of giraffe mitochondrial DNA supports the existence of an ancient rift valley that once separated populations in southern Africa and created the genetically distinct subspecies seen today; results with implications for both giraffe conservation and taxonomy.

    BMC Evolutionary Biology 2014, 14:219
  • Meta-analysis of human methylomes

    New evidence that methylation beyond the CpG island could play a role in gene expression.

    Epigenetics & Chromatin 2014, 7:28
  • Image attributed to: Flickr Jon Rawlinson

    What is the best treatment for canine epilepsy?

    Oral phenobarbital and imepitoin are amongst likely effective anti-epileptic drugs for the treatment of canine idiopathic epilepsy; however, poor reporting in literature preclude definitive recommendations prompting a need for greater blinded RCTs evaluating the efficacy of these drugs.

    BMC Veterinary Research 2014, 10:257
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