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    Drinking patterns change with age

    Alcohol consumption in the UK rises during adolescence and declines in mid-life, but frequent drinking is more common in older age, particularly among men, providing information about drinking patterns that could inform intervention strategies.

    BMC Medicine 2015, 13:47
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    Tumor microenvironment insights 

    Fei Chen and colleagues discuss the role of the tumor microenvironment (TME) in cancer progression, highlighting ways in which the TME can be targeted to improve therapeutic efficacy and reduce resistance in a personalized approach to cancer therapy. 

    BMC Medicine 2015, 13:45
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    Global mental health & ethics

    Dan Stein and James Giordano examine the intersections between global mental health and neuroethics, highlighting that collaborations should be fostered to facilitate the development of new technologies and progress of research on a global scale.

    BMC Medicine 2015, 13:44
  • The Stroke Hyperglycemia Insulin Network Effort (SHINE) trial: an adaptive trial design case study

    The ADAPT-IT project explores how adaptive designs can improve clinical trials. Using the SHINE trial as an example, two designs were evaluated, revised and improved using trial simulation to facilitate the understanding of the statistical properties of both.

    Trials 2015, 16:72
  • Intelligent control of epigenetic states

    The first review in the "Breakthroughs in clinical epigenetics" series provides an upate on synthetic epigenetics and the potential clinical applications of epigenome editing.

    Clinical Epigenetics 2015, 7:18
  • Recruiting to inpatient-based rehabilitation trials

    Recruitment to clinical trials is often challenging. A multi-center RCT recruiting stroke rehabilitation patients identified that the most successful strategies included using inclusive recruitment, ‘watchful waiting’, and structured engagement with the whole stroke multi-disciplinary team.

    Trials 2015, 16:75
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    Understanding neuropsychiatric lupus

    Yehuda Shoenfeld and colleagues review the challenges with diagnosis and management of neuropsychiatric lupus, and explore the possible link between disease symptoms and specific mechanisms which may help to inform development of future therapies.

    BMC Medicine 2015, 13:43
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    Successful HB immunization program in Fiji

    Hepatitis B serologic survey in Fiji during 2008-2009 demonstrated a significant reduction of HBV infection rates in children and adults since 1998, indicating the HB immunization program is very successful.

    Virology Journal 2015, 12:36
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    Managing pediatric malaria

    Kathryn Maitland reviews the complications and therapeutic challenges associated with malaria in African children, discussing new clinical trial data and future research priorities to improve pediatric malaria outcome in this high-burden setting.

    BMC Medicine 2015, 13:42
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    Preventing cardiometabolic disease

    Patricio Lopez-Jaramillo et al. discuss the link between maternal undernutrition, birth weight and cardiometabolic disease, emphasizing the importance of conducting research in Latin America to develop strategies for disease prevention in this setting.

    BMC Medicine 2015, 13:41
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