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  • Primary cilium as a mechanical and calcium signaling nexus

    The authors use Fluorescence Resonance Energy Transfer (FRET) to image calcium signalling in individual cilia, demonstrating the mechanism of mechanotransduction.

    Cilia 2015, 4:7
  • Image attributed to: Flickr, Medisave UK

    NCD risk factors prevalent in Africa

    Risk factors for non-communicable diseases (NCDs) are prevalent in Tanzanaia and Uganda, but the incidence of preventable NCDs is low, highlighting the need for prevention campaigns and early detection efforts to reduce NCD burden in Africa.

    BMC Medicine 2015, 13:126
  • Image attributed to: Flickr:  Nikolai Vassiliev

    Smoking exacerbates child poverty

    Parental smoking exacerbates poverty for a large proportion of children in the UK, suggesting tobacco control interventions which effectively enable low income smokers to quit can play an important role in reducing the financial burden of child poverty.

    BMC Public Health 2015, 15:507
  • Image attributed to: HIV cartoon

    HIV-1 treatment by RNAi

    John Rossi and colleages review the use of RNA interference against HIV-1 in the clinic, viral and host targets and strategies to overcome immunogenicity, toxicity and viral mutagenesis.

    Genome Medicine 2015, 7:50
  • Image attributed to: istock photo

    Malaria linked to hearing impairment

    In a study of malaria-affected children in Ghana, Gabon and Kenya, impairment in inner ear function occurs in 40% of those with cerebral malaria, suggesting that hearing evaluation should be considered following severe malaria infection.

    BMC Medicine 2015, 13:125
  • Image attributed to: Flickr CC (NIAID)

    Microvasculature linked to malaria severity

    Severity of adult malaria manifestations is linked to microvascular obstruction and endothelial activation, and these processes independently contribute to pathogenesis, suggesting that interventions targeting either pathway may have therapeutic potential.

    BMC Medicine 2015, 13:122
  • Cloning-free CRISPR/Cas system

    Bill Skarnes from Sanger Institute answers a burning question: Is mouse embryonic stem cell technology obsolete?

    Genome Biology 2015, 16:109
  • 3D chromatin domains

    An analysis integrating chromatin information and Hi-C data reveals features associated with topologically associating domains and nuclear compartments

    Genome Biology 2015, 16:110
  • Image attributed to: Caroline Fox

    New interaction between species found

    Remote camera capture and biological sample study identify an ecological, marine-terrestrial interaction between American black bears and Pacific herring during spawn events.

    BMC Ecology 2015, 15:14
  • HER2 heterogeneous cancer

    An analysis of HER2 heterogeneous breast cancers reveals an important role of the HER2 negative component of the HER2 positive tumors

    Genome Biology 2015, 16:107
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