The authors use Fluorescence Resonance Energy Transfer (FRET) to image calcium signalling in individual cilia, demonstrating the mechanism of mechanotransduction.
Risk factors for non-communicable diseases (NCDs) are prevalent in Tanzanaia and Uganda, but the incidence of preventable NCDs is low, highlighting the need for prevention campaigns and early detection efforts to reduce NCD burden in Africa.
Parental smoking exacerbates poverty for a large proportion of children in the UK, suggesting tobacco control interventions which effectively enable low income smokers to quit can play an important role in reducing the financial burden of child poverty.
John Rossi and colleages review the use of RNA interference against HIV-1 in the clinic, viral and host targets and strategies to overcome immunogenicity, toxicity and viral mutagenesis.
In a study of malaria-affected children in Ghana, Gabon and Kenya, impairment in inner ear function occurs in 40% of those with cerebral malaria, suggesting that hearing evaluation should be considered following severe malaria infection.
Severity of adult malaria manifestations is linked to microvascular obstruction and endothelial activation, and these processes independently contribute to pathogenesis, suggesting that interventions targeting either pathway may have therapeutic potential.
Bill Skarnes from Sanger Institute answers a burning question: Is mouse embryonic stem cell technology obsolete?
An analysis integrating chromatin information and Hi-C data reveals features associated with topologically associating domains and nuclear compartments
Remote camera capture and biological sample study identify an ecological, marine-terrestrial interaction between American black bears and Pacific herring during spawn events.
An analysis of HER2 heterogeneous breast cancers reveals an important role of the HER2 negative component of the HER2 positive tumors
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