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  • B. mandrillaris clinical metagenomics

    Sequencing and assembly of the Balamuthia mandrillaris genome allows metagenomic diagnosis in a case of encephalitis and underlines the importance of reference sequences.

    Genome Medicine 2015, 7:113
  • Treating sexually transmitted infections

    This Editorial sets the scene for the series in which we encounter the difficulties of treating antibiotic-resistant gonorrhoea and Mycoplasma genitalium; the continuing spread of chlamydia, syphilis and trichomoniasis, as well as management of non-gonococcal urethritis and bacterial vaginosis.

    BMC Infectious Diseases 2015, 15:337
  • Image attributed to: Detail of Figure 1 from Brown et al.

    Extracting TCR repertoires from RNA-seq data

    A novel analytical approach that allows extraction of T cell receptor sequence information directly from RNA sequencing data and that can be used to characterize tumor-associated T cell repertoires.

    Genome Medicine 2015, 7:125
  • Microbiome profiling from biopsies

    Doron Betel and colleagues describe methodology for the identification of pathogens from low bacterial abundance human WGS datasets

    Genome Biology 2015, 16:265
  • Image attributed to: iStock Photo

    PSA screening for prostate cancer

    Who and when to screen for prostate cancer using prostate-specific antigen (PSA) testing is highly controversial; in this forum article, Sigrid Carlsson and Andrew Vickers ask some of the world’s experts to discuss which men might benefit from screening.

    BMC Medicine 2015, 13:288
  • Supporting systematic reviews using LDA-based document representations

    Text mining methods to identify relevant studies during the screening stage of a systematic review are becoming more popular. During automatic citation screening, the LDA topic modelling approach results in a more informative representation of studies than the BOW model.

    Systematic Reviews 2015, 4:172
  • Image attributed to: Flickr cc European Commission/Martin Karimi

    Intervention measures reduce Ebola spread

    Transmission chain reconstruction modeling of an Ebola outbreak suggests containment of the disease depends on its natural history and intervention measures, arguing population awareness and strict compliance can strongly reduce widespread infection.

    BMC Medicine 2015, 13:281
  • Image attributed to: Flickr CC (DFID UK)

    NBC useful for defining cause of death

    The classic naive Bayes classifier (NBC) outperforms other automated classifiers for verbal autopsy when defining cause of death (COD), but further research is needed as no automated classifier adequately replicates physician classification of COD.

    BMC Medicine 2015, 13:286
  • Image attributed to: Influenza virus_from iStockPhoto

    B cell Rep-seq sheds light on Influenza immunity

    Longitudinal analysis of the B cell receptor repertoire after immunization with a new influenza virus strain reveals unique features in clonal structure, IGHV segment use and low somatic hypermutation levels.

    Genome Medicine 2015, 7:124
  • Down syndrome methylation

    Novel biological mechanisms are implicated in the development of Down syndrome by studying methylation patterns in humans and mice

    Genome Biology 2015, 16:263
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