John Rossi and colleages review the use of RNA interference against HIV-1 in the clinic, following the development of a number of viral and host targets as well as strategies to overcome immunogenicity, toxicity and viral mutagenesis.
Severity of adult malaria manifestations is linked to microvascular obstruction and endothelial activation, and these processes independently contribute to pathogenesis, suggesting that interventions targeting either pathway may have therapeutic potential.
An analysis integrating chromatin information and Hi-C data reveals features associated with topologically associating domains and nuclear compartments
Bill Skarnes from Sanger Institute answers a burning question: Is mouse embryonic stem cell technology obsolete?
An analysis of HER2 heterogeneous breast cancers reveals an important role of the HER2 negative component of the HER2 positive tumors
The high-resolution structure of the bovine adenovirus 4 fibre head was described, which is the first solved fibre head structure of an atadenovirus infecting a mammalian host.
Heavy drinking during special occasions accounts for the difference between sales of alcohol and surveyed amounts, indicating more accurate measures are required to monitor total alcohol consumption and the associated health risks.
In an interview-based study, South Asian mothers with gestational diabetes report conflicting advice from peers vs clinicians, and admit socio-cultural factors play a key role, so any behavioral interventions should take into account cultural factors.
Thomas Eissenberg and colleagues comment on the problems associated with variability in nicotine levels delivered by electronic cigarettes, and recommend that regulation is required to prevent an increase in nicotine dependence.
The first comprehensive reconstruction of the ancestral snakes, using both genetic and fossil data, provides insights into early snake evolution and presents a picture of the first snake’s appearance and lifestyle.
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