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  • Large-scale RNAi screens

    Beerenwinkel and colleagues describe a method identifying hits from large-scale RNAi screens and removing confounding effects due to miRNA-mediated off-target interactions

    Genome Biology 2015, 16:220
  • Treating sexually transmitted infections

    This Editorial sets the scene for the series in which we encounter the difficulties of treating antibiotic-resistant gonorrhoea and Mycoplasma genitalium; the continuing spread of chlamydia, syphilis and trichomoniasis, as well as management of non-gonococcal urethritis and bacterial vaginosis.

    BMC Infectious Diseases 2015, 15:337
  • Image attributed to: Baguelin et al.

    Flu vaccine likely to be cost-effective

    In an economic evaluation comparing extensions of the pre-2013 influenza vaccination program to various age groups, extending vaccine administration in children in the UK may be cost-effective and reduce disease burden in the general population.

    BMC Medicine 2015, 13:236
  • High cholesterol predicts RA in women but not men

    High total cholesterol is a risk factor for rheumatoid arthritis (RA) in women but not in men, suggesting that sex-specific exposures modify the impact of lipids on the risk of RA.

    Arthritis Research & Therapy 2015, 17:284
  • Image attributed to: Richard Hobbs

    Prevention of cardiovascular diseases

    In an editorial to launch our article collection on cardiovascular diseases, Guest Editor Richard Hobbs emphasizes research should focus on better diagnosis and interventions, and discusses how this collection aims to address some of the gaps in knowledge in the field.

    BMC Medicine 2015, 13:261
  • Image attributed to: istock

    Dying at home better than hospital 

    Bereaved relatives of those who died from cancer report that dying at home is associated with less grief and more peace compared with dying in hospital, but requires more family care, suggesting that discussion of preferences is needed. 

    BMC Medicine 2015, 13:235
  • Treatment non-adherence associated with higher disease activity

    Non-adherence to disease-modifying antirheumatic drugs in the first six months of treatment is a strong predictor of higher disease activity and thus contributes to failure in obtaining remission.

    Arthritis Research & Therapy 2015, 17:281
  • Image attributed to: Public Domain

    Northern lizards benefit from a warmer world

    During warmer years Swedish sand lizards lay their eggs earlier, a trait strongly linked to offspring survival, suggesting that for this population at the northern extremes of reptile ranges a warming climate could be beneficial.

    BMC Evolutionary Biology 2015, 15:206
  • Image attributed to: istock

    Risky behavior in repeat HIV testers 

    In a cohort study, voluntary repeat HIV testers are likely to engage in more risky sexual behaviors compared with single-testers, suggesting that analysis of testing patterns could reveal which groups are at highest risk of infection.

    BMC Medicine 2015, 13:218
  • Lokiarchaea and the missing link

    The great problem with the evolutionary origin of eukaryotes is the absence of intermediates. Eugene Koonin sets the recent startling discovery of the Lokiarchaea in the context of the complex issues arising in the attempt to fill the gap between bacteria and modern eukaryotes.

    BMC Biology 2015, 13:84
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