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  • Treating sexually transmitted infections

    This Editorial sets the scene for the series in which we encounter the difficulties of treating antibiotic-resistant gonorrhoea and Mycoplasma genitalium; the continuing spread of chlamydia, syphilis and trichomoniasis, as well as management of non-gonococcal urethritis and bacterial vaginosis.

    BMC Infectious Diseases 2015, 15:337
  • Image attributed to: Flickr CC (DFID UK)

    NBC useful for defining cause of death

    The classic naive Bayes classifier (NBC) outperforms other automated classifiers for verbal autopsy when defining cause of death (COD), but further research is needed as no automated classifier adequately replicates physician classification of COD.

    BMC Medicine 2015, 13:286
  • Down syndrome methylation

    Novel biological mechanisms are implicated in the development of Down syndrome by studying methylation patterns in humans and mice

    Genome Biology 2015, 16:263
  • S. aureus alternative Cas9

    A characterization of an alternative, Staphylococcus aureus-derived Cas9 nuclease and the design of all-in-one vector

    Genome Biology 2015, 16:257
  • Image attributed to: Detail of Figure 4 from Dean et al.

    Annotation of TCR pseudogenic gene segments

    A new method based on high-throughput sequencing of the TCR locus of a large cohort of healthy individuals reveals functional and non-functional alleles of individual TCRβ V gene segments.

    Genome Medicine 2015, 7:123
  • The perivascular origin of mesenchymal stem cells

    Iain Murray and Bruno Peault explain in question and answer form why we should care about where mesenchymal stem cells come from. They have been successfully isolated from cell cultures for decades and administered in hundreds of clinical trials, but a better understanding of their role in vivo holds promise for their more effective use in regenerative medicine.

    BMC Biology 2015, 13:99
  • p16 DNA methylation drives metastasis

    Engineered zinc finger methyltransferases provide insights into the role of p16 methylation in cancer metastasis

    Genome Biology 2015, 16:252
  • Image attributed to: Fesoj, via Wikipedia, CC2.0

    An elusive history

    The largest morphological dataset ever assembled of Ditrysia, which comprise 99% of butterflies and moths, contributes new information on the diversity and distribution of this super-group and provides a platform to resolve the many mysteries surrounding their evolution.

    BMC Evolutionary Biology 2015, 15:260
  • Image attributed to: Detail of Figure 3 from Kanduri et al.

    Novel Th cell lineage-specific genes and lncRNAs

    Transcriptional analysis of naïve and polarized T cells integrating three different approaches reveals a high-confidence list of Th1 and Th2 lineage-specific protein-coding genes and long non-coding RNAs.

    Genome Medicine 2015, 7:122
  • Image attributed to: Wikipedia; Gary van der Merwe

    Towards a cure for HIV

    Eradicating latent viruses remains a major challenge for curing HIV infection; Hui Zhang and colleagues review current understanding of the mechanisms of viral latency, and discuss recent advances in the development of a functional cure for HIV.

    BMC Medicine 2015, 13:284
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