This Editorial sets the scene for the series in which we encounter the difficulties of treating antibiotic-resistant gonorrhoea and Mycoplasma genitalium; the continuing spread of chlamydia, syphilis and trichomoniasis, as well as management of non-gonococcal urethritis and bacterial vaginosis.
The classic naive Bayes classifier (NBC) outperforms other automated classifiers for verbal autopsy when defining cause of death (COD), but further research is needed as no automated classifier adequately replicates physician classification of COD.
Novel biological mechanisms are implicated in the development of Down syndrome by studying methylation patterns in humans and mice
A characterization of an alternative, Staphylococcus aureus-derived Cas9 nuclease and the design of all-in-one vector
A new method based on high-throughput sequencing of the TCR locus of a large cohort of healthy individuals reveals functional and non-functional alleles of individual TCRβ V gene segments.
Iain Murray and Bruno Peault explain in question and answer form why we should care about where mesenchymal stem cells come from. They have been successfully isolated from cell cultures for decades and administered in hundreds of clinical trials, but a better understanding of their role in vivo holds promise for their more effective use in regenerative medicine.
Engineered zinc finger methyltransferases provide insights into the role of p16 methylation in cancer metastasis
The largest morphological dataset ever assembled of Ditrysia, which comprise 99% of butterflies and moths, contributes new information on the diversity and distribution of this super-group and provides a platform to resolve the many mysteries surrounding their evolution.
Transcriptional analysis of naïve and polarized T cells integrating three different approaches reveals a high-confidence list of Th1 and Th2 lineage-specific protein-coding genes and long non-coding RNAs.
Eradicating latent viruses remains a major challenge for curing HIV infection; Hui Zhang and colleagues review current understanding of the mechanisms of viral latency, and discuss recent advances in the development of a functional cure for HIV.
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