Plasmodium parasites that infect rodents are promising laboratory models for human malaria, but our ability to interrogate their biology has been limited by a scarcity of genomic data. As a comprehensive resource for future research, Otto and colleagues have generated a wealth of genomic, transcriptomic and genotype diversity data.
In a modeling study, active case finding (ACF) for tuberculosis (TB) is highly cost-effective in India, China and South Africa, and long-term gains outweigh high initial costs, highlighting that ACF should be considered as a tool for TB control.
Carbapenem-resistant Acinetobacter spp. sepsis patients in the ICU are at risk of inappropriate initial antibiotic therapy, a predictor of hospital mortality, indicating the need for novel diagnostic tools and concerted efforts to prevent the spread of resistant organisms
Rachel Ellaway comments on the recently published STructured apprOach to the Reporting In healthcare education of Evidence Synthesis (STORIES) statement, highlighting that it will enable research to be translated into medical education practice.
RNA polymerase III complexes, when bound to DNA, regulate RNA polymerase II transcription of neighboring genomic regions.
MSEA detects cancer genes by targeting unique characteristics of mutation hotspots with improved precision and reduced false positive discovery
Characterization of calling errors for INDEL detection using Scalpel shows that calling improves with higher coverage, is better with assembly-based callers is discordant between WGS and WES.
Genome-wide association studies mapped 90% of loci linked to autoimmune and immune-related diseases to non-coding regions. A ‘guilt by association’ approach suggests a role for lncRNAs in autoimmunity.
Peter de Jonge and Annelieke Roest comment on research published in BMC Cardiovascular Disorders showing a J-shaped relationship between cardiometabolic risk factors and depression, highlighting the need to consider non-linear associations in medicine
Gene expression signatures of infiltrating immune cells provide prognostic and therapy-predictive information for breast cancer and are affected by tumor proliferative capacity and intrinsic subtype.
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