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  • Rodent malaria genomics

    Plasmodium parasites that infect rodents are promising laboratory models for human malaria, but our ability to interrogate their biology has been limited by a scarcity of genomic data. As a comprehensive resource for future research, Otto and colleagues have generated a wealth of genomic, transcriptomic and genotype diversity data.

    BMC Biology 2014, 12:86
  • Image attributed to: Flickr CC (The Speaker)

    TB active case finding is cost-effective

    In a modeling study, active case finding (ACF) for tuberculosis (TB) is highly cost-effective in India, China and South Africa, and long-term gains outweigh high initial costs, highlighting that ACF should be considered as a tool for TB control.

    BMC Medicine 2014, 12:216
  • Image attributed to: Calleamanecer on Wikipedia

    Inappropriate antibiotics for sepsis

    Carbapenem-resistant Acinetobacter spp. sepsis patients in the ICU are at risk of inappropriate initial antibiotic therapy, a predictor of hospital mortality, indicating the need for novel diagnostic tools and concerted efforts to prevent the spread of resistant organisms

    BMC Infectious Diseases 2014, 14:572
  • Image attributed to: istock

    Medical education reporting

    Rachel Ellaway comments on the recently published STructured apprOach to the Reporting In healthcare education of Evidence Synthesis (STORIES) statement, highlighting that it will enable research to be translated into medical education practice.

    BMC Medicine 2014, 12:193
  • RNA polymerase crosstalk

    RNA polymerase III complexes, when bound to DNA, regulate RNA polymerase II transcription of neighboring genomic regions.

    BMC Biology 2014, 12:89
  • MSEA: mutation hotspots

    MSEA detects cancer genes by targeting unique characteristics of mutation hotspots with improved precision and reduced false positive discovery

    Genome Biology 2014, 15:489
  • Image attributed to: From Fig 6 of Lyon and colleagues

    INDEL calling WGS versus WES

    Characterization of calling errors for INDEL detection using Scalpel shows that calling improves with higher coverage,  is better with assembly-based callers is discordant between WGS and WES.

    Genome Medicine 2014, 6:89
  • Image attributed to: From Fig 1 of Hrdlickova and colleagues

    ‘Guilt by association’ in AID

    Genome-wide association studies mapped 90% of loci linked to autoimmune and immune-related diseases to non-coding regions.  A ‘guilt by association’ approach suggests a role for lncRNAs in autoimmunity.

    Genome Medicine 2014, 6:88
  • Image attributed to: istock photo

    Depression and cardiovascular risk

    Peter de Jonge and Annelieke Roest comment on research published in BMC Cardiovascular Disorders showing a J-shaped relationship between cardiometabolic risk factors and depression, highlighting the need to consider non-linear associations in medicine

    BMC Medicine 2014, 12:199
  • Image attributed to: breast tumor via Wikimedia commons

    Immune metagene roles in therapy response

    Gene expression signatures of infiltrating immune cells provide prognostic and therapy-predictive information for breast cancer and are affected by tumor proliferative capacity and intrinsic subtype.

    Genome Medicine 2014, 6:80
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