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  • Treating sexually transmitted infections

    This Editorial sets the scene for the series in which we encounter the difficulties of treating antibiotic-resistant gonorrhoea and Mycoplasma genitalium; the continuing spread of chlamydia, syphilis and trichomoniasis, as well as management of non-gonococcal urethritis and bacterial vaginosis.

    BMC Infectious Diseases 2015, 15:337
  • Supporting systematic reviews using LDA-based document representations

    Text mining methods to identify relevant studies during the screening stage of a systematic review are becoming more popular. During automatic citation screening, the LDA topic modelling approach results in a more informative representation of studies than the BOW model.

    Systematic Reviews 2015, 4:172
  • Image attributed to: Flickr cc European Commission/Martin Karimi

    Intervention measures reduce Ebola spread

    Transmission chain reconstruction modeling of an Ebola outbreak suggests containment of the disease depends on its natural history and intervention measures, arguing population awareness and strict compliance can strongly reduce widespread infection.

    BMC Medicine 2015, 13:281
  • Image attributed to: Flickr CC (DFID UK)

    NBC useful for defining cause of death

    The classic naive Bayes classifier (NBC) outperforms other automated classifiers for verbal autopsy when defining cause of death (COD), but further research is needed as no automated classifier adequately replicates physician classification of COD.

    BMC Medicine 2015, 13:286
  • Image attributed to: Influenza virus_from iStockPhoto

    B cell Rep-seq sheds light on Influenza immunity

    Longitudinal analysis of the B cell receptor repertoire after immunization with a new influenza virus strain reveals unique features in clonal structure, IGHV segment use and low somatic hypermutation levels.

    Genome Medicine 2015, 7:124
  • Down syndrome methylation

    Novel biological mechanisms are implicated in the development of Down syndrome by studying methylation patterns in humans and mice

    Genome Biology 2015, 16:263
  • S. aureus alternative Cas9

    A characterization of an alternative, Staphylococcus aureus-derived Cas9 nuclease and the design of all-in-one vector

    Genome Biology 2015, 16:257
  • Image attributed to: Detail of Figure 4 from Dean et al.

    Annotation of TCR pseudogenic gene segments

    A new method based on high-throughput sequencing of the TCR locus of a large cohort of healthy individuals reveals functional and non-functional alleles of individual TCRβ V gene segments.

    Genome Medicine 2015, 7:123
  • The perivascular origin of mesenchymal stem cells

    Iain Murray and Bruno Peault explain in question and answer form why we should care about where mesenchymal stem cells come from. They have been successfully isolated from cell cultures for decades and administered in hundreds of clinical trials, but a better understanding of their role in vivo holds promise for their more effective use in regenerative medicine.

    BMC Biology 2015, 13:99
  • p16 DNA methylation drives metastasis

    Engineered zinc finger methyltransferases provide insights into the role of p16 methylation in cancer metastasis

    Genome Biology 2015, 16:252
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