An analysis of HER2 heterogeneous breast cancers reveals an important role of the HER2 negative component of the HER2 positive tumors
The high-resolution structure of the bovine adenovirus 4 fibre head was described, which is the first solved fibre head structure of an atadenovirus infecting a mammalian host.
Heavy drinking during special occasions accounts for the difference between sales of alcohol and surveyed amounts, indicating more accurate measures are required to monitor total alcohol consumption and the associated health risks.
In an interview-based study, South Asian mothers with gestational diabetes report conflicting advice from peers vs clinicians, and admit socio-cultural factors play a key role, so any behavioral interventions should take into account cultural factors.
Thomas Eissenberg and colleagues comment on the problems associated with variability in nicotine levels delivered by electronic cigarettes, and recommend that regulation is required to prevent an increase in nicotine dependence.
The first comprehensive reconstruction of the ancestral snakes, using both genetic and fossil data, provides insights into early snake evolution and presents a picture of the first snake’s appearance and lifestyle.
Closely related wood white butterfly species substantially differ in chromosome number and structure including, remarkably, possession of unique sex chromosome constitutions in each species, supporting an important role for chromosome rearrangements in speciation.
Towards core outcome set development: a follow-up descriptive survey of outcomes in Cochrane reviews
Core outcome sets can help reduce research waste by addressing outcome reporting bias and heterogeneity. Between 2007 and 2013, Cochrane reviews have increased the proportion of reported outcomes and explanations behind non-reported outcomes.
Lawrence Kelley and Michael Sternberg discuss the bioinformatic challenges in studying partial protein domains, and what can we learn from them
A robust method for cellular phenotyping in primary human mesenchymal stem cells using kinome fingerprinting to identify gene networks that characterize distinct primary cell populations.
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