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  • Colon cancer 5hmC

    Promoters 5-hydroxymethylated during normal colon differentiation are resistant to neoplastic hypermethylation

    Genome Biology 2015, 16:69
  • Human genomic history

    Pugach and Stoneking provide genome-wide insights into the genetic history of human populations in Southern Africa, India, Oceania, Island South East Asia and the Americas.

    Investigative Genetics 2015, 6:6
  • Inferring positive selection in humans from genomic data

    Wollstein and Stephan discuss the two competing models of adaptation and suitable approaches for detecting the footprints of positive selection on humans at the molecular level.

    Investigative Genetics 2015, 6:5
  • Image attributed to: Prostate cancer cells from an organoid, produced by NIH

    Organoid cancer models

    Michael Cantrell and Cavlin Kuo discuss recent developments in the three-dimensional culture of organoids and their promise for both bottom-up and top-down screening to find cancer drivers.

    Genome Medicine 2015, 7:32
  • Image attributed to: Flickr (CC, Ed Uthman)

    Artemisinin resistance genetics

    Carol Sibley discusses recent findings on the genetic changes associated with artemisinin resistance in P. falciparum parasites, highlighting the importance of understanding the evolution of resistance to maintain antimalarial effectiveness.

    BMC Medicine 2015, 13:67
  • Laryngeal tuberculosis diagnosed by stool sample cultures

    With current methods, laryngeal tuberculosis is commonly misdiagnosed. Evidence suggests that stool cultures could be used in the diagnosis of atypical forms of tuberculosis; this is the first case report to describe the successful use of stool cultures in tuberculosis diagnosis.

    Journal of Medical Case Reports 2015, 9:74
  • Image attributed to: istock photo

    Fixed dosed AS-AQ optimal for malaria

    In a meta-analysis of artesunate-amodiaquine (AS-AQ) treatment for malaria, there is variation in the AQ dose administered under different regimens and fixed dose combinations provide high efficacy, highlighting the importance of correct dosing in malaria treatment.

    BMC Medicine 2015, 13:66
  • Image attributed to: Flickr:  Michael Dorausch

    Youth accessing e-cigarettes for experimentation

    E-cigarettes are being accessed by teenagers more for experimentation than smoking cessation and mostly by those who engage in other substance-related risk behaviours including regular smoking, binge drinking and alcohol-related violence.

    BMC Public Health 2015, 15:244
  • Image attributed to: Santosa et al.

    Reduced burden of NCDs met by Sweden

    Sweden, a country at a late stage of epidemiological transition, has exceeded the  target of 25% reduction in premature mortality due to non-communicable diseases (NCDs), suggesting other countries at earlier stages of development may achieve this goal.

    BMC Medicine 2015, 13:65
  • ceRNAs: tying the essential knots for cancer biology and therapeutics

    Sanchez-Mejias and Tay review recent discoveries that implicate competing endogenous RNAs (ceRNAs), or natural miRNA sponges, in human cancer. The authors explain how identifying ceRNA regulatory networks can aid the development of new approaches to cancer diagnostics and oligonucleotide-based therapeutics.

    Journal of Hematology & Oncology 2015, 8:30
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