Promoters 5-hydroxymethylated during normal colon differentiation are resistant to neoplastic hypermethylation
Pugach and Stoneking provide genome-wide insights into the genetic history of human populations in Southern Africa, India, Oceania, Island South East Asia and the Americas.
Wollstein and Stephan discuss the two competing models of adaptation and suitable approaches for detecting the footprints of positive selection on humans at the molecular level.
Michael Cantrell and Cavlin Kuo discuss recent developments in the three-dimensional culture of organoids and their promise for both bottom-up and top-down screening to find cancer drivers.
Carol Sibley discusses recent findings on the genetic changes associated with artemisinin resistance in P. falciparum parasites, highlighting the importance of understanding the evolution of resistance to maintain antimalarial effectiveness.
With current methods, laryngeal tuberculosis is commonly misdiagnosed. Evidence suggests that stool cultures could be used in the diagnosis of atypical forms of tuberculosis; this is the first case report to describe the successful use of stool cultures in tuberculosis diagnosis.
In a meta-analysis of artesunate-amodiaquine (AS-AQ) treatment for malaria, there is variation in the AQ dose administered under different regimens and fixed dose combinations provide high efficacy, highlighting the importance of correct dosing in malaria treatment.
E-cigarettes are being accessed by teenagers more for experimentation than smoking cessation and mostly by those who engage in other substance-related risk behaviours including regular smoking, binge drinking and alcohol-related violence.
Sweden, a country at a late stage of epidemiological transition, has exceeded the target of 25% reduction in premature mortality due to non-communicable diseases (NCDs), suggesting other countries at earlier stages of development may achieve this goal.
Sanchez-Mejias and Tay review recent discoveries that implicate competing endogenous RNAs (ceRNAs), or natural miRNA sponges, in human cancer. The authors explain how identifying ceRNA regulatory networks can aid the development of new approaches to cancer diagnostics and oligonucleotide-based therapeutics.
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