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    Immune toxicity with anti-CTLA-4 therapy

    In a systematic review and meta-analysis, nearly a quarter of patients undergoing anti-CTLA-4 cancer treatment develop immune-related adverse events, suggesting better knowledge of side effects can reduce morbidity and therapy cessation.

    BMC Medicine 2015, 13:211
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    Economic impact of vaccination needs innovative research

    Estimation of the broad and long-term benefits of vaccines and immunisation programmes is challenging due to limited research, and as identified by this systematic review and conceptual framework of causal pathways, innovative research is needed to address the gaps.

    BMC Medicine 2015, 13:209
  • Diet versus exercise

    Results from the SHAPE-2 trial show the importance of physical activity as a positive intervention to decrease breast cancer risk.

    Breast Cancer Research 2015, 17:120
  • SMRT sequencing in plants

    Combination of SMRT and Illumina reads provide comprehensive gene sets for newly sequenced genomes of non-model organisms sugar beet and spinach

    Genome Biology 2015, 16:184
  • Hi-C analysis methods

    Ferhat Ay and William Noble review computational tools for analyzing Hi-C data

    Genome Biology 2015, 16:183
  • Image attributed to: Wollum et al. BMC Medicine

    Variation in MCH gains across Nigeria

    Nigeria has made significant national gains in maternal and child health (MCH) since 2000, but with substantial variations across districts and among interventions, highlighting areas of priority for policy makers to better inform local decision-making.

    BMC Medicine 2015, 13:208
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    Targeting resistance in CRPC

    Christopher Evans and colleagues discuss the mechanisms underlying resistance to treatments for castration-resistant prostate cancer (CRPC), outlining how the pathways involved could be targeted to overcome therapy resistance.

    BMC Medicine 2015, 13:206
  • Retinopathy phenotype severity

    Phenotype severity in mouse models of CRX-associated retinopathies correlates with graded gene expression changes

    Genome Biology 2015, 16:171
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    Joint healthcare management

    Glyn Elwyn et al. discuss the relationship between clinical practice guidelines for clinicians and decision support for patients, stressing that decision making in healthcare requires collaboration, and trustworthy evidence is needed for success.

    BMC Medicine 2015, 13:199
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    Is EBM biased against patients?

    Although patient and carer consultation in evidence-based medicine (EBM) has improved, Trish Greenhalgh et al. argue that biases, including power imbalances between patient and physician can hinder progress of EBM, and suggest ways in which these biases can be minimized.

    BMC Medicine 2015, 13:200
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    Reproducibility: what are we going to do about it?

    As an increasing number of studies reveal that much of science is not able to be reproduced or replicated, BioMed Central launched the pilot of a new Minimum Standards of Reporting Checklist.

    The checklist addresses three areas of reporting: experimental design and statistics, resources, and availability of data and materials.

    As well as posting a blog to summarize the main features, a launch editorial was published, where BioMed Central staff and the Editors of GigaScience and Genome Biology stressed the need for ensuring the reproducibility of scientific work.

     

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    Tropical Diseases, Travel Medicine and Vaccines has launched

    This is the first open access journal in the field of travel medicine and the first journal to focus on intersecting topics in tropical diseases, travel medicine and vaccines.  Considering the increased mobility of world populations and increasing globalization of world economies, the journal meets the growing need for the dissemination of research with strong implications for world health and medicine.


    Read more about it in the editorial 'The local importance of global infectious diseases'.

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    Chinese Neurosurgical Journal has now fully launched

    The journal covers all areas of neurosurgery, including new trends in neurology and neuroscience, with a focus on clinical practice and techniques. We publish it on behalf of the Chinese Neurosurgical Association, which fully sponsors the article processing charges for authors.

    The Editor-in-Chief Jizong Zhao is a leading expert in neurosurgery in China and also an academician of Chinese Academy of Sciences.

    Click here to find out why you should publish in this journal.

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    Women’s Midlife Health has fully launched

    "We seek to stimulate increased scientific and clinical focus on the midlife and its relevance to health and healthy aging," says Editor-in-Chief Dr. Siobán D. Harlow of the University of Michigan. Find out more about the aims of the journal in her launch editorial

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