-
- Erratum in:
- Aliment Pharmacol Ther 1994 Jun;8(3):357.
Short report: treatment of gastric ulcer with lansoprazole or ranitidine: a multicentre clinical trial.
Hôpital Charles Nicolle, Rouen, France.
We studied the effectiveness of lansoprazole and ranitidine in promoting gastric ulcer healing in a multicentre double-blind trial, by comparing the proportion of healed ulcers after 4 and 8 weeks of treatment. One hundred and fifty-eight patients were randomly given either ranitidine (150 mg each morning and at bedtime) or lansoprazole (30 mg each morning and placebo at bedtime). One hundred and twenty-eight patients completed the trial (62 taking lansoprazole, 66 taking ranitidine). Fifty-one (80%) of those treated with lansoprazole and forty-two (62%) of those treated with ranitidine had healed ulcers at 4 weeks (P < 0.05). Sixty-one (98%) patients who received lansoprazole and 57 (86%) who received ranitidine had healed ulcers at 8 weeks (P < 0.05). The observed differences were not significant in the intention-to-treat analysis. No serious adverse event was reported with lansoprazole.
PMID: 8186337 [PubMed - indexed for MEDLINE]
-
Related Articles
-
Patient Drug Information
-
Ranitidine (Tritec®, Zantac®, Zantac® 75, ...)
Ranitidine is used to treat ulcers; gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and injury of the food pipe (esophagus); and conditions where the s...
-
Omeprazole (Prilosec®, Prilosec® OTC, Zegerid®)
Prescription omeprazole is used alone or with other medications to treat ulcers (sores in the lining of the stomach or small intestine), gastroesophageal reflux disease (GERD), a condition in which backward flow of acid ...
-
Esomeprazole (Nexium®)
Esomeprazole is used to treat gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and injury of the esophagus (food pipe between the mouth and stomach) in ...
» See all 4 Drug Reports ...