Cytoplasmic dynein could be key to understanding n...[Genome Biol. 2008]

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1: Genome Biol. 2008;9(3):214. Epub 2008 Mar 28. Links

Cytoplasmic dynein could be key to understanding neurodegeneration.

Banks GT, Fisher EM.

Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK. g.banks@prion.ucl.ac.uk.

A new mouse mutation, Sprawling, highlights an essential role for the dynein heavy chain in sensory neuron function, but it lacks the ability of other known heavy-chain mutations to ameliorate neurodegeneration due to defective superoxide dismutase.

PMID: 18373888 [PubMed - indexed for MEDLINE]

PMCID: PMC2397497

Mutant superoxide dismutase disrupts cytoplasmic dynein in motor neurons. [Neuroreport. 2005]
Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex. [J Biol Chem. 2007]
Proprioceptive sensory neuropathy in mice with a mutation in the cytoplasmic Dynein heavy chain 1 gene. [J Neurosci. 2007]
ReviewAxonal transport and neurodegenerative disease. [Biochim Biophys Acta. 2006]
ReviewThe wobbler mouse: a neurodegeneration jigsaw puzzle. [Mol Neurobiol. 2003]

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Cytoplasmic dynein could be key to understanding neurodegeneration.

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