Integrative analysis for finding genes and network...[Genome Biol. 2007]

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1: Genome Biol. 2007;8(11):R253. Links

Integrative analysis for finding genes and networks involved in diabetes and other complex diseases.

Bergholdt R, Størling ZM, Lage K, Karlberg EO, Olason PI, Aalund M, Nerup J, Brunak S, Workman CT, Pociot F.

Steno Diabetes Center, Niels Steensensvej 2, DK-2820 Gentofte, Denmark. rber@steno.dk

We have developed an integrative analysis method combining genetic interactions, identified using type 1 diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.

PMID: 18045462 [PubMed - indexed for MEDLINE]

PMCID: PMC2258178

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ReviewHLA complex genes in type 1 diabetes and other autoimmune diseases. Which genes are involved? [Trends Genet. 2001]
Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. [Diabetes. 2005]
ReviewGenetic susceptibility factors of Type 1 diabetes in Asians. [Diabetes Metab Res Rev. 2001]

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Integrative analysis for finding genes and networks involved in diabetes and other complex diseases.

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