The emerging role of lysophosphatidic acid in canc...[Nat Rev Cancer. 2003]

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1: Nat Rev Cancer. 2003 Aug;3(8):582-91. Links

The emerging role of lysophosphatidic acid in cancer.

Mills GB, Moolenaar WH.

MD Anderson Cancer Center, Houston, Texas 77030, USA. gmills@mdanderson.org

The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis. The recent identification of ecto-enzymes that mediate the production and degradation of LPA, as well as the development of receptor-selective analogues, indicate mechanisms by which LPA production or action could be modulated for cancer therapy.

PMID: 12894246 [PubMed - indexed for MEDLINE]

ReviewBioactive lysophospholipids and their G protein-coupled receptors. [Exp Cell Res. 1999]
ReviewBeta-catenin, cancer, and G proteins: not just for frizzleds anymore. [Sci STKE. 2005]
ReviewLysophosphatidic acid is a bioactive mediator in ovarian cancer. [Biochim Biophys Acta. 2002]
Lysophosphatidic acid: G-protein signalling and cellular responses. [Curr Opin Cell Biol. 1997]
TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. [J Biol Chem. 2004]

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The emerging role of lysophosphatidic acid in cancer.

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