Complex genetic diseases: controversy over the Cro...[Genome Biol. 2001]

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1: Genome Biol. 2001;2(8):COMMENT2007. Epub 2001 Aug 1. Links

Complex genetic diseases: controversy over the Croesus code.

Wright AF, Hastie ND.

MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK. alan.wright@hgu.mrc.ed.ac.uk

The polarization of views on how best to exploit new information from the Human Genome Project for medicine reflects our ignorance of the genetic architecture underlying common diseases: are susceptibility alleles common or rare, neutral or deleterious, few or many? Single-nucleotide polymorphism (SNP) technology is almost in place to dissect such diseases and to create a personalized medicine, but success is critically dependent on the biology and "Nature to be commanded must be obeyed" (Francis Bacon, 1620, Novum Organum).

PMID: 11532206 [PubMed - indexed for MEDLINE]

PMCID: PMC138948

The common variants/multiple disease hypothesis of common complex genetic disorders. [Med Hypotheses. 2004]
A haplotype map of the human genome. [Physiol Genomics. 2003]
Are rare variants responsible for susceptibility to complex diseases? [Am J Hum Genet. 2001]
ReviewOn selecting markers for association studies: patterns of linkage disequilibrium between two and three diallelic loci. [Genet Epidemiol. 2003]
ReviewMapping the new frontier: complex genetic disorders. [J Clin Invest. 2005]

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Complex genetic diseases: controversy over the Croesus code.

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