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Charles Swanton and colleagues review the ins and outs of intratumor heterogeneity and how does it affect personalized medicine
Obi Griffith, Andrew Su and colleagues discuss the challenges of combining the genomic knowledge and N-of-1 studies to improve personalized medicine
David Adams and colleagues discuss the elegant approach for the cancer evolution studies, combining sequencing with the clever choice of cancer models
An analysis of sporadic renal cell carcinoma case reveals new insights about evolutionary principles affecting tumor development
Tumor evolution in a diffuse gastric cancer patient and cancer modeling reveals the metastatic contribution of Tgfbr2 loss-of-function
A new statistical framework for the reconstruction of tumor clone structure
A comprehensive genome-scale study of multiple solid tumors showed that hypomethylated blocks are a universal feature of common solid tumors and occur early in malignancy.
Whole genome and transcriptome sequencing of matched tumor-normal tissue for hepatocellular carcinoma cases reveals low frequency mutations associated with the disease
Specific factors are associated with risk of cardiovascular disease; Robert Eckel and Marc-Andre Cornier review the data and recommendations on the use of these biomarkers to help identify patients who need intensive cholesterol-lowering therapy.
Hickman and Dyda discuss a new superfamily of mobile elements, designated casposons, that are likely to be bona fide DNA transposons, and are possibly still active.
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